文献类型：期刊文献

中文题名：油酸对小鼠急性镉中毒的缓解作用及镉残留的影响

英文题名：Effect of oleic acid on acute cadmium poisoning and cadmium residue in mice

作者：王靖雯[1];陈泽娜[1];高健[1];王雅玲[1];房志家[1];孙力军[1];聂方红[1]

机构：[1]广东海洋大学食品科技学院广东省水产品加工与安全重点实验室广东省海洋食品工程技术研究中心水产品深加工广东普通高等学校重点实验室寸金学院教务处

年份：2019

卷号：36

期号：4

起止页码：50

中文期刊名：生物学杂志

外文期刊名：Journal of Biology

收录：CSTPCD、、北大核心2017、CSCD_E2019_2020、北大核心、CSCD

基金：国家自然科学基金(31701706);广东海洋大学科研启动经费资助项目(R17102)

语种：中文

中文关键词：油酸;镉中毒;镉残留;肝脏;肾脏

外文关键词：oleic acid;cadmium poisoning;cadmium residue;liver;kidney

中文摘要：为探究油酸对小鼠急性镉中毒的缓解作用及机制,选用105只SPF级昆明小鼠检测油酸对急性镉毒和镉残留的影响,通过连续7d给急性镉中毒小鼠灌胃不同剂量的油酸(10、15和20mg/kg·d),检测小鼠的体重变化、脏器指数及镉蓄积,并比较油酸与常用解毒剂维生素C(VC)在急性镉中毒小鼠的缓解作用。结果显示,与维生素C相比,15和20mg/kg·d油酸灌胃能够更有效地缓解镉中毒引起的体重下降;与VC能够显著改善镉造成的肝脏器官指数的结果相比,油酸对肝肾器官指数并没有显著改善作用。进一步探索发现油酸与VC均可显著降低肝、肾组织中镉残留。结果表明,相对于维生素C,油酸能够更有效地降低镉在小鼠肝、肾组织中的蓄积,缓解小鼠急性镉中毒。

外文摘要：To explore the alleviated effect of oleic acid on acute cadmium poisoning in mice and its mechanism, 105 SPF Kunming mice were used for acute cadmium toxicity and residue testing. The acute cadmium poisoning mice were orally administered of different doses of oleic acid (10, 15 and 20 mg/kg per day) by 7-day continuously gavage, after then the changes of body weight, liver/kidney index and their cadmium residue were tested, to compare the alleviated effect of oleic acid and vitamin C, a routine antidote, on acute cadmium poisoning of mice. Comparing to vitamin C, 15 and 20 mg/kg·d of oleic acid can more significantly alleviate the body weight loss caused by cadmium exposure. Comparing to significant reduction of liver index by vitamin C, the reduction of liver and kidney index by the oleic acid is not significant. More important, oleic acid significantly reduced the cadmium residue in liver and kidney tissue. The result suggests that compared to vitamin C, the oleic acid can more significantly alleviate the acute cadmium poisoning through efficiently reducing the accumulation of cadmium in liver and kidney in mice.