文献类型：期刊文献

英文题名：A high-efficiency automatic pressure-relief drug transfer device for anticancer medications with superior closed performance

作者：Xie, Liming[1];Chen, Guanfeng[1];Ouyang, Qianqian[2];Quan, Weiyan[2];Xie, Xiaoming[1];Chen, Xiaoling[1];Li, Lefan[3];Li, Sidong[3];Chen, Rizhi[4];Luo, Rongqiong[4];Qiu, Zhiqing[1]

机构：[1]Guangdong Med Univ, Affiliated Hosp, Dept Pharm, Zhanjiang, Peoples R China;[2]Guangdong Med Univ, Sch Ocean & Trop Med, Zhanjiang, Guangdong, Peoples R China;[3]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang, Peoples R China;[4]Guangdong Jianliyuan Med Technol Co Ltd, Zhanjiang, Peoples R China

年份：2025

卷号：16

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：SCI-EXPANDED(收录号：WOS:001483739800001)、、Scopus(收录号：2-s2.0-105004473693)、WOS

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This study was supported by Project of Traditional Chinese Medical of Guangdong Province (B2024217).

语种：英文

外文关键词：closed performance; automatic pressure-relief; hazardous drugs; closed-system drugtransfer device; occupational protection; CSTD

外文摘要：Objective Preventing exposure to hazardous drugs is crucial for healthcare workers to avoid health risks. To mitigate healthcare workers' risks when handling hazardous drugs, we developed a novel closed-system drug-transfer device (CSTD) called CSTD(JLY). This CSTD has an automatic pressure-relief structure. Hence, it can significantly decrease the resistance in the push/pull of a piston rod if an operator transfers drugs, thereby reducing the burden on the hands of the operator during drug transfer.Methods We investigated the closed performance of the novel CSTD (JLY) by comparing it with the performance of a syringe. We selected a simulation drug (fluorescein sodium), commonly used drugs (lansoprazole, nimodipine, and tropisetron), and a commonly used anti-cancer agent (cyclophosphamide) to conduct exposure evaluation.Results Compared with a syringe, CSTD(JLY) could reduce drug leakage significantly. Our novel CSTD with an automatic pressure-relief structure had superior closed performance. CSTD(JLY) could solve the problem of liquid-drug leakage during drug transfer.Conclusion This feature could reduce the exposure risk healthcare workers and patients.