文献类型：期刊文献

英文题名：Catechin Mediates Ferroptosis to Exert an Anti-Inflammatory Effect on RAW 264.7 Cells

作者：Kuang, Weiyang[1];Yang, Jiajia[1];Liu, Zhiyuan[1];Zeng, Jinzi[1];Xia, Xuewei[1];Chen, Xiaodan[1];Zhong, Saiyi[2];Huang, Riming[1]

机构：[1]South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Food Qual & Safety, Guangzhou 510642, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China

年份：2022

卷号：11

期号：11

外文期刊名：FOODS

收录：SCI-EXPANDED(收录号：WOS:000809035100001)、、Scopus(收录号：2-s2.0-85131676471)、WOS

基金：This work was financially supported by the National Natural Science Foundation of China (No. 32161160304), the Macao Science and Technology Development Fund (No. 0069/2021/AFJ), Key-Area Research and Development Program of Guangdong Province (No. 2020B1111030004), Program of Department of Natural Resources of Guangdong Province (No. GDNRC [2021]53), The Innovative Team Program of High Education of Guangdong Province (2021KCXTD021).

语种：英文

外文关键词：catechin; anti-inflammatory; ferroptosis; molecular mechanism

外文摘要：Catechin possesses a potential anti-inflammatory activity, but its anti-inflammatory mechanism is still unclear. Herein, the analysis of network pharmacology showed that catechin might mediate ferroptosis on macrophages to exhibit a significant anti-inflammatory effect on RAW264.7. The metabolomics further indicated that catechin might influence ferroptosis by activating two pathways of cysteine and methionine metabolism and glutathione metabolism, and inhibiting the pathway of ferroptosis to promote the reduction of 1-methionine-s-oxide and s-glutathionyl-1-cysteine, and the reduction and synthesis of gamma-glutamylcysteine. Furthermore, related proteins (MSRA, CDR, GSR and GCL) in three metabolic pathways and ferroptosis-related proteins (GPX4 and SLC7A11) might be relevant to catechin through molecular docking. Thus, we speculate that catechin plays an anti-inflammatory effect through mediating ferroptosis on RAW264.7, which still needs further focus on the detailed molecular mechanism.