文献类型：期刊文献

英文题名：Modulation of Crustacean Innate Immune Response by Amino Acids and Their Metabolites: Inferences From Other Species

作者：Huang, Zishu[1,2,3];Aweya, Jude Juventus[1,2,3];Zhu, Chunhua[4];Tran, Ngoc Tuan[1,2,3];Hong, Yujian[5];Li, Shengkang[1,2,3];Yao, Defu[1,2,3];Zhang, Yueling[1,2,3]

机构：[1]Shantou Univ, Inst Marine Sci, Shantou, Peoples R China;[2]Shantou Univ, Guangdong Prov Key Lab Marine Biotechnol, Shantou, Peoples R China;[3]Shantou Univ, Shantou Univ Univ Malaysia Terengganu STU UMT Joi, Shantou, Peoples R China;[4]Guangdong Ocean Univ, Coll Fisheries, Zhanjiang, Peoples R China;[5]Guangdong Yuequn Marine Biol Res & Dev Co Ltd, Jieyang, Peoples R China

年份：2020

卷号：11

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000592362800001)、、Scopus(收录号：2-s2.0-85096217909)、WOS

基金：This work was sponsored by National Natural Science Foundation of China (No.31872596), Department of Education of Guangdong Province (No.2017KZDXM033), and Science and Technology Planning Project of Guangdong Province (2017B020245001).

语种：英文

外文关键词：crustaceans; amino acids; metabolism; immune-modulation; innate immunity

外文摘要：Aquaculture production of crustaceans (mainly shrimp and crabs) has expanded globally, but disease outbreaks and pathogenic infections have hampered production in the last two decades. As invertebrates, crustaceans lack an adaptive immune system and mainly defend and protect themselves using their innate immune system. The immune system derives energy and metabolites from nutrients, with amino acids constituting one such source. A growing number of studies have shown that amino acids and their metabolites are involved in the activation, synthesis, proliferation, and differentiation of immune cells, as well as in the activation of immune related signaling pathways, reduction of inflammatory response and regulation of oxidative stress. Key enzymes in amino acid metabolism have also been implicated in the regulation of the immune system. Here, we reviewed the role played by amino acids and their metabolites in immune-modulation in crustaceans. Information is inferred from mammals and fish where none exists for crustaceans. Research themes are identified and the relevant research gaps highlighted for further studies.