文献类型：期刊文献

英文题名：Biodegradable and biocompatible supramolecular polymers based on poly (?-caprolactone-co-?-valerolactone)-b-poly(lactide) block copolymers with different branched structures: Synthesis, crystallization and properties

作者：Jing, Zhanxin[1];Huang, Xiaolan[1];Li, Guifeng[1];Liao, Mingneng[1];Hong, Pengzhi[2];Li, Yong[1];Shi, Xuetao[3]

机构：[1]Guangdong Ocean Univ, Coll Chem & Environm, Dept Appl Chem, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[3]Northwestern Polytech Univ, Coll Chem & Chem Engn, Xian 710129, Peoples R China

年份：2022

卷号：181

外文期刊名：EUROPEAN POLYMER JOURNAL

收录：SCI-EXPANDED(收录号：WOS:000884840800004)、、EI(收录号：20224413043290)、Scopus(收录号：2-s2.0-85140892452)、WOS

基金：Acknowledgments This work was supported by the National Natural Science Foundation of China (52003060) , the Natural Science Foundation of Guangdong Province (2018A030307020) , College Featured Innovation Project of Guangdong Province (2020KTSC052) , Science and Technology Plan Project of Zhanjiang City (2020A01027) and Nanhai Scholars Talent Funding Program of Guangdong Ocean University (002029002012) .

语种：英文

外文关键词：Poly(lactide); Supramolecular polymers; Stereocomplexation

外文摘要：A novel biodegradable supramolecular polymer (SMP) was successfully synthesized via self-complementary quadruple hydrogen bonding-driven poly(epsilon-caprolactone-co-delta-valerolactone)-b-poly(lactide) (PCVL-b-PLA) block copolymers. The SMP structure was analyzed by 1H NMR, GPC and the gel content, and found that the formation of self-complementary quadruple hydrogen bonds between UPy dimers not only expanded the polymer molecular chain, but also formed a cross-linked network structure for three-arm or four-arm branched PCVL-b- PLLA block copolymers. The results of WAXD and DSC indicated that compared with the precursor, the crys-tallization ability of supramolecular polymer was suppressed, but the stereocomplexation was conducive to the SMP crystallization. The tensile strength, elongation at break and tensile modulus were highly tunable and range from 7.1 -25.3 MPa, 588 -1860 % and 9.1 -21.4 MPa, respectively. The branching structure and ster-ecomplexation significantly adjusted the hydrophilicity and degradation of SMP. In addition, the synthesized SMP were evaluated for their biocompatibility by performing MTT assay using mouse fibroblasts (L929), indi-cating their high biocompatibility. The development of biodegradable and biocompatible supramolecular polymers may offer a new choice for tissue regeneration application.