文献类型：期刊文献

英文题名：Association analysis between variants in bovine NPY gene and growth traits in Nanyang cattle (Bos torus)

作者：Zhang, Li[1,2];Zhang, Ai-Ling[1,3];Zhang, Liang-Zhi[1];Zhang, Qin[1];Zhang, Chun-Lei[1,4];Lan, Xian-Yong[1];Chen, Hong[1]

机构：[1]NW A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China;[2]Guangdong Ocean Univ, Coll Agr, Zhanjiang 524088, Peoples R China;[3]S China Agr Univ, Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China;[4]Xuzhou Normal Univ, Coll Lifesci, Xuzhou 221000, Peoples R China

年份：2011

卷号：170

期号：1

起止页码：189

外文期刊名：GENERAL AND COMPARATIVE ENDOCRINOLOGY

收录：SCI-EXPANDED(收录号：WOS:000286367400019)、、WOS

基金：This study was supported by the National 863 Program of China (No. 2008AA101010), National Natural Science Foundation of China (No. 30972080), National Key Technology R&D Program (No. 2008BADB2B03-19), Keystone Project of transfergene in China (Nos. 2009ZX08009-157B, 2008ZX08007-002, 2009ZX08007-005B-07), Program of National Beef Cattle Industrial Technology System (No. Nycytx-38).

语种：英文

外文关键词：Neuropeptide Y; Single nucleotide polymorphism; Growth traits; Cattle

外文摘要：Neuropeptide Y (NPY) is one of the most potent orexigenic factors that is implicated in the control of feeding behavior and energy homeostasis. Four Chinese indigenous cattle breeds (n = 338) were used to detect single nucleotide polymorphisms (SNPs) in the coding regions with their intron-exon boundaries and the proximal flanking regions of NPY gene by PCR-SSCP and DNA sequencing. Five novel SNPs (38017 C > G, 34240 C > A, 34168 G > A. 32463 A > C and 32302 C > G) were identified. Polymorphisms of P3 lous in NPY gene, containing SNP4 and SNP5, were associated with body length and chest girth in Nanyang cattle aged 6, 12 and 18 months (P < 0.05), but they had no significant effect on the two growth traits in Nanyang cattle aged 24 months (P > 0.05). The results open a new field of study and extend the spectrum of genetic variation of the bovine NPY gene, which might contribute to cattle genetic resources and breeding. (C) 2010 Published by Elsevier Inc.