文献类型：期刊文献

英文题名：Chromolaena odorata as a potential feed additive bioresource to alleviate heat stress in chickens in the humid tropics

作者：Lartey, Kwame Ayisi[1];Kang, Dan-Ju[1];Zhang, Qiao-Hui[1];Shi, Chao-Qun[1];Yang, Fan[1];Lin, Hong-Ying[1];Gooneratne, Ravi[2];Chen, Jin-Jun[1]

机构：[1]Guangdong Ocean Univ, Coll Agr Sci, Dept Vet Med, Zhanjiang 524088, Guangdong, Peoples R China;[2]Lincoln Univ, Fac Agr & Life Sci, Dept Wine Food & Mol Biosci, Lincoln, New Zealand

年份：2020

卷号：76

期号：1

起止页码：119

外文期刊名：WORLDS POULTRY SCIENCE JOURNAL

收录：SCI-EXPANDED(收录号：WOS:000588138800010)、、Scopus(收录号：2-s2.0-85117062428)、WOS

基金：This work was supported by the Science and Technology Program Foundation of Guangdong Province [Zhanjiang Special Competitive Allocation Project].

语种：英文

外文关键词：Antioxidation; anti-inflammation; anti-stress; gut health; heat stress

外文摘要：Chromolaena odorata (commonly known as Jack in the Bush, a thoroughwort of the Aster family) contains polyphenols and antioxidant enzymes that activate biology defence mechanisms and stress-sensing transcription factors to prevent oxidative damage and heat stress in chicken. Dietary inclusions of C. odorata leaf meal at 12%, and C. odorata crude flavonoids at 400 mg/kg/d have been shown to exert competitive exclusion effects to enhance gut eubiosis, humoral immunity, hypoglycaemia and metabolic functions necessary to attenuate oxidative stress in chickens. Ethanol extract of the plant at 25-400 mu g/ml showed a strong antioxidant capacity in vitro, similar to 10-80 mu g/ml standard ascorbic acid administration. Chromomoric acid C-1 from C. odorata methanol extract, at 10 mu g, demonstrated anti-inflammatory potential by activating Nrf2 and suppressing NF-kappa B in a luciferase reporter assay at an inhibition capacity (IC50) of 6.9 mu M. These biological defence properties of this plant have the potential to maintain microbial homeostasis and gut integrity, enhance antioxidative physiology for cellular oxidative balance, and mitigate oxidative damage in the presence of heat stress. The invasive nature of the plant in the humid tropics makes it a readily available and a cheap bioresource. Hepatotoxic, mutagenic and cytotoxic evaluations suggested that the aerial parts of the herbal plant are safe for use in animal nutrition.