文献类型：期刊文献

英文题名：Inhibition effects of 7-phloro-eckol from Ecklonia cava on metastasis and angiogenesis induced by hypoxia through regulation of AKT/mTOR and ERK signaling pathways

作者：Yang, Shengtao[1,2];Liu, Yi[1];Xiao, Zhenbang[1,2];Tang, Yanfei[1];Hong, Pengzhi[1,2];Sun, Shengli[1];Zhou, Chunxia[1,2];Qian, Zhong-Ji[1,2]

机构：[1]Guangdong Ocean Univ, Shenzhen Inst, Coll Food Sci & Technol, Sch Chem & Environm, Zhanjiang 524088, Peoples R China;[2]Southern Marine Sci & Engn Guangdong Lab, Zhanjiang 524025, Peoples R China

年份：2021

卷号：14

期号：6

外文期刊名：ARABIAN JOURNAL OF CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000657695800017)、、EI(收录号：20212010359311)、Scopus(收录号：2-s2.0-85105735690)、WOS

基金：The research was funded by the Natural Science Foundation of Guangdong Province (2020A1515011075) and the Yangfan Scarce Top Talent Project of Guangdong Province (201433009) . The research was supported by the 2020 Shenzhen International Scientific and Technological Cooperation R&D Project, support was provided by Guangdong Tongde Pharmaceutical Co., Ltd and funded by the Development Project about Marine Economy Demonstration of Zhanjiang City (2017C8B1) . In addition, the research was funded by the Fund of Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang, ZJW201907) .

语种：英文

外文关键词：7-phloro-eckol; Ecklonia cava; Hepatoma; Hypoxia; Metastasis; Angiogenesis

外文摘要：As one of the malignant tumors with high mortality, liver cancer has the characteristics of early invasion and metastasis, and lacks effective treatment methods. Therefore, it is urgent to find new safe, efficient and low-toxic anti-liver cancer drugs. In this study, the evaluated mechanism of Ecklonia cava polyphenols (7PE, 7-phloro-eckol) as a potential active substance for inhibiting liver cancer metastasis (HepG2 cell) and angiogenesis (HUVEC cell). The results have shown that 7PE can inhibit the expression of hypoxia-inducible factors (HIF-1a) protein by regulating the PI3K/AKT/mTOR and Ras/MEK/ERK/MNK signaling pathways under hypoxic conditions in HepG2 cells, thereby blocking the secretion of vascular growth factor (VEGF) protein. At the same time, 7PE can significantly inhibit the conduction of AKT and MAPK signaling pathways in HUVEC by suppressing the activation of VEGFR-2 protein, which verifies the prediction of molecular docking. Therefore, the results of this study provide a research basis for 7PE to inhibit metastasis and angiogenesis of liver cancer cells, and provide a theoretical basis for the high-value utilization of Ecklonia cava. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).