文献类型：期刊文献

英文题名：Chitosan-based Nano-biocomposites and their Applications in Medicine and Pharmaceutics

作者：Yang, Ziming[1,2];Li, Puwang[2];McDonagh, Andrew[3];Li, Sidong[4];Lv, Mingzhe[2];Li, Yongzhen[2];Yu, Ziyang[5];Feng, Changgen[1]

机构：[1]Beijing Inst Technol, Mech & Engn Dept, Zhongguancun South St 5, Beijing 100081, Peoples R China;[2]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China;[3]Univ Technol Sydney, Dept Chem & Biomol Engn, Sydney, NSW 2007, Australia;[4]Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Peoples R China;[5]Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China

年份：2018

卷号：22

期号：7

起止页码：628

外文期刊名：CURRENT ORGANIC CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000432913900003)、、EI(收录号：20241916061372)、Scopus(收录号：2-s2.0-85049002927)、WOS

基金：This work was jointly supported by The Natural Science Foundation of Guangdong Province (No. 2016A030307003, No. 2016A030308009), and the financial support by the Central Public interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (No.1630122017011, No.1630122017009).

语种：英文

外文关键词：Chitosan; nano-biocomposites; medicine; pharmaceutics; application; preparation

外文摘要：Background: Chitosan-based nano-biocomposite has received more and more attentions in the past few years because of the outstanding merits that chitosan is a natural polymer with biodegradable and biocompatible. Objective: The purpose of the present study is to summarize the different preparation methods of chitosan-based nano-biocomposites, such as electrostatic interaction method, preparation of chitosan-based nano-biocomposites from modified chitosan using self assembly technique, chemical crosslinking approach, metal ions coordination and metal nanoparticles compound methods. In addition, the applications of chitosan-based nanobiocomposites in wound dressing, drug delivery, tissue engineering and biosensors are also discussed. Results: The results show that chitosan-based nano-biocomposites based on nanoparticles or nanohydrogel that can deliver drugs directly to cancer cells at a sustained and controlled rate may provide better efficacy and lower toxicity for the treatment of cancer. Furthermore, chitosan-based nano-biocomposites can enhance the properties of unmodified chitosan and improve the amphipathy, physical and mechanical properties of chitosan and produce new biological functions. Conclusion: It is believed that the rapid development of nano-science and technology must brought broad application prospects for the chitosan-based nano-biocomposites.