文献类型：期刊文献

英文题名：Transcriptomic insights into cessation of clam embryonic development following transgenerational exposure to ocean acidity extreme

作者：Xu, Yang[1];Luo, Xin[1];Masanja, Fortunatus[1];Deng, Yuewen[1];Zhao, Liqiang[1,2,3]

机构：[1]Guangdong Ocean Univ, Fisheries Coll, Zhanjiang, Peoples R China;[2]Guangdong Ocean Univ, Guangdong Sci & Technol Innovat Ctr Marine Inverte, Zhanjiang, Peoples R China;[3]Guangdong Ocean Univ, Guangdong Prov Key Lab Aquat Anim Dis Control & Hl, Zhanjiang, Peoples R China

年份：2024

卷号：198

外文期刊名：MARINE ENVIRONMENTAL RESEARCH

收录：SCI-EXPANDED(收录号：WOS:001244597200001)、、EI(收录号：20242116133930)、Scopus(收录号：2-s2.0-85193740908)、WOS

基金：The present study has been made possible by grants from the National Science Foundation of China (42076121, M-0163, 42211530423) , the Department of Education of Guangdong Province (2020KTSCX050 and 2022ZDZX4012) , the China Scholarship Council (NO. 2023-21) , the Guangdong Zhujiang Talents Program (2021QN02H665) , and the program for Scientific Research Start-up Funds of Guangdong Ocean University.

语种：英文

外文关键词：Ocean acidity extreme; Transgenerational impact; Molecular response; Marine bivalves; Ruditapes philippinarum

外文摘要：Ocean acidity extremes (OAX) events are becoming more frequent and intense in coastal areas in the context of climate change, generating widespread consequences on marine calcifying organisms and ecosystems they support. While transgenerational exposure to end-of-century scenario of ocean acidification (i.e., at pH 7.7) can confer calcifiers resilience, whether and to what extent such resilience holds true under OAX conditions is still poorly understood. Here, we found that transgenerational exposure of Ruditapes philippinarum to OAX resulted in cessation of embryonic development at the trochophore stage, implying devastating consequences of OAX on marine bivalves. We identified a large number of differentially expressed genes in embryos following transgenerationally exposed to OAX, which were mainly significantly enriched in KEGG pathways related to energy metabolism, immunity and apoptosis. These pathways were significantly activated, and genes involved in these processes were up-regulated, indicating strong cellular stress responses to OAX. These findings demonstrate that transgenerational exposure to OAX can result in embryonic developmental cessation by severe cellular damages, implying that transgenerational acclimation maybe not a panacea for marine bivalves to cope with OAX, and hence urgent efforts are required to understand consequences of intensifying OAX events in coastal ecosystems.