文献类型：期刊文献

英文题名：Preparation and Properties of Carboxymethyl Chitosan/Alginate/Tranexamic Acid Composite Films

作者：Zhong, Qing-Kun[1];Wu, Ze-Yin[1];Qin, Ya-Qi[1];Hu, Zhang[1];Li, Si-Dong[1];Yang, Zi-Ming[2];Li, Pu-Wang[2]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

年份：2019

卷号：9

期号：1

外文期刊名：MEMBRANES

收录：SCI-EXPANDED(收录号：WOS:000459730700011)、、EI(收录号：20191006600955)、Scopus(收录号：2-s2.0-85062398043)、WOS

基金：This work was funded by the Guangdong Provincial Natural Science Foundation of China (2016A030308009), the Project of Science and Technology Plan of Guangdong Province (2015A020216019), the Project of Enhancing School with Innovation of Guangdong Ocean University (2017KTSCX090) and the National Guangdong Ocean University Undergraduate Training Programs for Innovation and Entrepreneurship (CXXL2018035).

语种：英文

外文关键词：carboxymethyl chitosan; sodium alginate; tranexamic acid; composite films; hemostatic activity

外文摘要：In this study, the porous composite films of carboxymethyl chitosan/alginate/tranexamic acid were fabricated, with calcium chloride as the crosslinking agent and glycerin as a plasticizer. The composite films were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The properties of the composite films, including water absorption, air permeability, and cumulative release rate, were tested. In addition, their hemostatic performance was evaluated. The results showed that the appearance of the films with good adhesion was smooth and porous. FTIR showed that chemical crosslinking between carboxymethyl chitosan and sodium alginate was successful. The excellent cumulative release of tranexamic acid in the composite films (60-80%) gives the films a significant procoagulant effect. This has good prospects for the development of medical hemostasis materials.