文献类型：期刊文献

英文题名：Collagen peptides derived from sea bass scales (Lateolabrax maculatus) relieve photoaging through MAPK, NF-κB and TGF-β signaling pathways and modulating gut microbiota composition

作者：Liu, Dongcheng[1]; Ren, Yongxin[1]; Peng, Ye[2]; Zhong, Saiyi[3,4]; Xu, Baojun[1]

机构：[1] Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai, 519087, China; [2] Faculty of Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China; [3] Shenzhen Research Institute, Guangdong Ocean University, Shenzhen, 518108, China; [4] Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, 524088, China

年份：2025

卷号：221

外文期刊名：Food Research International

收录：EI(收录号：20253919217069)

语种：英文

外文关键词：Biochemistry - Collagen - Mammals - Peptides

外文摘要：This study investigated the effects of collagen peptides (CPs) derived from sea bass scales on UV-induced photoaging in nude mice. After UV exposure, mice treated with CPs demonstrated remarkable improvements compared to the model group, including an increase in skin hydration from 8.7 ± 2.16 to 24.11 ± 3.76 A.U., a boost in skin elasticity from 51.25 ± 3.06 to 131.25 ± 17.08, a restoration of collagen volume fraction from 32.53 ± 2.54 % to 59.54 ± 7.61 %, and a reduction in epidermal thickness from 90.64 ± 5.88 μm to 37.92 ± 2.61 μm. Mechanistically, CPs inhibited MAPK and NF-κB pathways, decreasing MMP-1 levels from 16.27 ± 4.34 μg/g to 4.38 ± 0.59 μg/g and activating TGF-β pathway. Additionally, CPs modulated gut microbiota composition, normalizing Muribaculaceae and Lactobacillaceae abundance. LEfSe analysis identified biomarkers including Muribaculum and Parabacteroides, indicating potential in mitigating photoaging and enhancing gut health through the gut-skin axis. ? 2025 Elsevier Ltd