文献类型：期刊文献

英文题名：Photoaging induced by long-term exposure to UV irradiation and amelioration by Skipjack tuna skin hydrolysates: Targeting inhibition of MAPK and NF-ΚB signaling hyperactivation

作者：Xu, Defeng[1];Zhao, Mouming[2,3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Marine Food, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Guangdong, Peoples R China;[2]South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China;[3]South China Univ Technol, Guangzhou 510610, Peoples R China

年份：2022

卷号：98

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：SCI-EXPANDED(收录号：WOS:000874119100006)、、WOS

基金：Funding This investigation was financially supported by the State Key Research and Development Plan (No. 2017YFD0400200) and the Fundamental Research Funds for the Central Universities (No. 20152M062) .

语种：英文

外文关键词：Photoaging; Skipjack tuna hydrolysates; Oxidant stress; Inflammation; Cascading signaling pathways

外文摘要：Excessive and long-term exposure of skin to UV irradiation induces the photoaging and previous reports have revealed the roles of oxidative stress and inflammation response in photoaging progression, which provides the potential targets for photoaging intervention. Herein, the low molecular weight hydrolysates obtained from Skipjack tuna skin (STH) were used to evaluate the ameliorating effects on photoaging and the action mechanism was further explored. Pathologically, STH significantly recovered the barrier functions and restored the impaired architectures of photoaging skin. Biochemically, the antioxidant capacity was remarkably elevated and the in-flammatory cytokines were significantly reduced in photoaging skin when STH was simultaneously adminis-trated. Moreover, the abnormalities in epidermal hyperplasia and dermal loss were dramatically improved, along with the significant increase of procollagen type I expression and inhibition of MMP-1 activity (P < 0.05). Furthermore, STH mitigated the phosphorylation levels of p38, JNK, ERK, I kappa B and p65 in photoaging skin, which strongly indicated that STH synergistically intervened the photoaging progression in SD rats via cascading modulation on the hyperactivation of MAPK and NF-kappa B signaling pathways. Overall, these data prove the desirable protection of STH against photoaging process and can be used as functional ingredients in cosme-ceutical foods.