文献类型：期刊文献

英文题名：Hepatoprotective effect of ultrafine powder of dendrobium officinale against acetaminophen-induced liver injury in mice

作者：Kong, Song-Zhi[1]; Lin, Guo-Sheng[2,3]; Liu, Jing-Jing[2,3]; Su, Ling-Ye[4,5]; Zeng, Lei[4,5]; Luo, Dan-Dan[2,5]; Su, Zi-Ren[2,3]; Wang, Hong-Feng[4,5]

机构：[1] Guangdong Ocean University, Faculty of Chemistry and Environmental Science, Zhanjiang, Guangdong, 524088, China; [2] Guangzhou University of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou, Guangdong, 510006, China; [3] Guangzhou University of Chinese Medicine, Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou, Guangdong, 510006, China; [4] Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangzhou, Guangdong, 510000, China; [5] Guangdong Academy of Forestry, Guangzhou, Guangdong, 510520, China

年份：2018

卷号：24

期号：2

起止页码：339

外文期刊名：Food Science and Technology Research

收录：EI(收录号：20184105912759)、Scopus(收录号：2-s2.0-85054322379)

语种：英文

外文关键词：Mammals - Cell death - Plants (botany) - Diseases - Amino acids

外文摘要：The aim of this study was to investigate the hepatoprotective effect of ultrafine powder of Dendrobium officinale (UDO) against acetaminophen (APAP)-induced liver injury in mice. ICR mice were orally administered with UDO (100, 200, 400 mg/kg/day) for 14 days before intraperitoneal injection of APAP. The results showed that UDO exhibited a significant dose-dependently preventive effect on APAP-induced hepatotoxicity. Pretreatment with UDO significantly reduced the serum levels of alanine transaminase and aspartate aminotransferase. Histological examination indicated that administration with UDO alleviated inflammation and necrosis as well as ameliorated hepatocyte steatosis, especially at 200 and 400 mg/kg doses. Additionally, UDO markedly recovered the activities of glutathione, catalase and total antioxidant capacity, and decreased the content of malonaldehyde and reactive oxygen species. In summary, the results suggested that pretreatment with UDO exists potently hepatoprotective effects against APAP-induced liver damage, which may be related to the enhanced antioxidant capacity and inhibited lipid peroxidation. ? 2018, Japanese Society for Food Science and Technology.