文献类型：期刊文献

英文题名：Biomimetic triumvirate nanogel complexes via peptide-polysaccharide-polyphenol self-assembly

作者：Tai, Min-Rui[1];Ji, Hong-Wu[1];Chen, Jian-Ping[1];Liu, Xiao-Fei[1];Song, Bing-Bing[1];Zhong, Sai-Yi[1];Rifai, Aaqil[2,3,4];Nisbet, David R.[4,5,6];Barrow, Colin J.[2];Williams, Richard J.[2,3,4];Li, Rui[1,7]

机构：[1]Guangdong Ocean Univ, Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Marine Food,Gu, Zhanjiang 524008, Peoples R China;[2]Deakin Univ, Ctr Sustainable Bioprod, Waurn Ponds, Vic 3217, Australia;[3]Deakin Univ, Sch Med, IMPACT, Waurn Ponds, Vic 3217, Australia;[4]Univ Melbourne, Graeme Clark Inst, Melbourne, Australia;[5]Univ Melbourne, Fac Engn & Informat Technol, Dept Biomed Engn, Melbourne, Australia;[6]Univ Melbourne, Med Sch, Fac Med Dent & Hlth Sci, Melbourne, Australia;[7]1 Haida Rd, Zhanjiang, Guangdong, Peoples R China

年份：2023

卷号：251

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001068351800001)、、EI(收录号：20233514647584)、Scopus(收录号：2-s2.0-85168802457)、WOS

基金：This work was funded by the General Project of Natural Science Foundation of Guangdong Province (grant number 2021A1515010868) , the Guangdong Province Ordinary Universities Characteristic Innovation Project (grant number 2020KTSCX051) , the Innovative Team Program of High Education of Guangdong Province (grant number 2021KCXTD021) , the Open Project of Key Laboratory of Functional Food, Ministry of Agriculture (grant number 202107) , and the Program for Scientific Research Start-up Funds of Guangdong Ocean University (grant number R20078) .

语种：英文

外文关键词：Fucoidan; Self-assembling peptides; Nanogel; Hesperidin; In vitro release

外文摘要：Self-assembled peptide and polysaccharide nanogels are excellent candidates for bioactive delivery vectors. However, there are still significant challenges in the application of nanogels as delivery tools for bioactive elements. This study aims to deliver, and control the release of a hydrophobic bioactive flavonoid hesperidin. Using the self-assembling peptide (SAP) Fmoc-FRGDF, extracellular matrix mimicking nanofibrils were fabricated, which were decorated and bolstered with immunomodulatory polysaccharide strands of fucoidan and infused with hesperidin. The mechanical properties, secondary structure, and microscopic morphologies of the composite hydrogels were characterized using rheometer, FTIR, XRD, and TEM, etc. The encapsulation efficiency (EE) and release behavior of hesperidin were determined. Coassembly of the SAP with fucoidan improved the mechanical properties (from 9.54 Pa of Fmoc-FRGDF hydrogel to 7735 Pa of coassembly hydrogel at 6 mg/mL fucoidan concentration), formed thicker nanofibril bundles at 4 and 6 mg/mL fucoidan concentration, improved the EE of hesperidin from 72.86 % of Fmoc-FRGDF hydrogel to over 90 % of coassembly hydrogels, and showed effectively controlled release of hesperidin in vitro. Intriguingly, the first order kinetic model predicted an enhanced hydrogel retention and release of hesperidin. This study revealed a new approach for bioengineered nanogels that could be used to stabilize and release hydrophobic payloads.