文献类型：期刊文献

英文题名：Engineering pH-responsive hyaluronic acid-tilapia protein Pickering emulsions for intestinal targeted delivery of quercetin

作者：Liu, Qingguan[1,2,3];Hong, Pengzhi[1,2,3];Li, Xiang[1,2,3];Ma, Huanta[1,2,3];Xie, Mengya[1,2,3];Zhou, Chunxia[1,2,3]

机构：[1]Guangdong Ocean Univ, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Coll Food Sci & Technol,Guangdong Prov Engn Techno, Guangdong Prov Engn Lab Marine Biol Prod,Guangdong, Zhanjiang 524088, Peoples R China;[2]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China;[3]Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Zhanjiang 524088, Peoples R China

年份：2026

卷号：407

外文期刊名：JOURNAL OF FOOD ENGINEERING

收录：SCI-EXPANDED(收录号：WOS:001612612900001)、、WOS

基金：This work was supported by the Guangdong Provincial Modern Agricultural Industry Technology System Innovation Team Construction Project (2023KJ150), the Zhanjiang Science and Technology Plan Project (2022A05037), and the Guangdong Ocean University Research Start-up Fund (060302042317).

语种：英文

外文关键词：Composite emulsion; Quercetin; Rheology; Stability; Digestive properties

外文摘要：This study aims to investigate the feasibility of using Pickering emulsions stabilized by hyaluronic acid (HA)tilapia protein isolate (TPI) complexes formed via pH-driven methods for the intestinal delivery of quercetin at different concentrations (0.1, 0.2, 0.4, 0.6, 0.8 mg/mL). The results showed that the emulsion with quercetin concentration of 0.6 mg/mL had the highest encapsulation efficiency (95.2 %). Quercetin loading led to an increase in the particle size and zeta potential of the emulsions and significantly improved the rheological properties. The composite emulsion loading significantly increased the scavenging rate of quercetin for DPPH and ABTS+ radicals, and efficiently enhanced the light, heat and storage stability of quercetin. The composite emulsion maintained structural integrity during simulated gastric fluid (pH 2) digestion and rapid release of free fatty acids in simulated intestinal fluid (pH 7) digestion, which exhibits pH-responsive behavior in its digestive performance and effectively improved quercetin retention and bioaccessibility. Therefore, the composite emulsion is expected to serve as a pH-responsive oral delivery vehicle for lipid-soluble polyphenols such as quercetin to improve their digestion and absorption characteristics.