文献类型：期刊文献

英文题名：Dydrogesterone Affects the Transcription of Genes in Innate Immune and Coagulation Cascade in Zebrafish Embryos

作者：Shi, Wen-Jun[1,2,3,4];Liang, Yan-Qiu[5];Zhao, Jian-Liang[1,2,3];Hu, Li-Xin[1,2,3];Huang, Guo-Yong[1,2,3];Ying, Guang-Guo[1,2,3]

机构：[1]South China Normal Univ, SCNU Environm Res Inst, Guangdong Prov Key Lab Chem Pollut & Environm Saf, Guangzhou 510006, Peoples R China;[2]South China Normal Univ, SCNU Environm Res Inst, MOE Key Lab Theoret Chem Environm, Guangzhou 510006, Peoples R China;[3]South China Normal Univ, Sch Environm, Guangzhou 510006, Peoples R China;[4]Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China;[5]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China

年份：2021

卷号：106

期号：4

起止页码：594

外文期刊名：BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

收录：SCI-EXPANDED(收录号：WOS:000617074500001)、、EI(收录号：20210709923283)、Scopus(收录号：2-s2.0-85100735545)、WOS

基金：The authors thank the National Natural Science Foundation of China for (NSFC 41807480), China Postdoctoral Science Foundation (2018M643116) for financial support and Guangdong Provincial Natural Science Foundation (No. 2016A030306033).

语种：英文

外文关键词：Dydrogesterone; Innate immune; Coagulation cascade; Zebrafish

外文摘要：Dydrogesterone (DDG) acts on the reproduction but also affects the functioning of non-reproductive system. So far, the knowledge about other effects of DDG remains limited. Here we investigated the effects of DDG on the transcription of genes in innate immune and coagulation cascade in zebrafish embryos. The zebrafish embryos were exposed to DDG at 49.0, 527 and 5890 ng L- 1 for 144 hour post fertilization (hpf). The results showed that DDG significantly decreased the transcription of marker genes (e.g. tnfa, il8 and cc-chem) involved in the innate immune response at environmental concentrations. Moreover, DDG also down-regulated the transcription of genes in coagulation cascade (e.g. fga, fgb, fgg and f2). These results indicated that DDG had potential effects on the innate immune and coagulation cascade functions in the early life zebrafish, thus further affecting fish growth and health.