文献类型：期刊文献

英文题名：Nutritional Appraisal and Antidiabetic Activity of a Kind of Mixed Plasma Proteolytic Peptide from Tachpleus tridentatus

作者：Kang, Xinhuang[1];Zhang, Guoguang[1];Wu, Yulian[1];Deng, Chunmei[1]

机构：[1]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Peoples R China

年份：2022

卷号：10

期号：10

外文期刊名：JOURNAL OF MARINE SCIENCE AND ENGINEERING

收录：SCI-EXPANDED(收录号：WOS:000875214400001)、、Scopus(收录号：2-s2.0-85140992516)、WOS

基金：This research was funded by the National Science Foundation from Guangdong Ocean University (No. GDOU2017052502) and the National Science Foundation from the Zhanjiang Technology Bureau (No. A15445, A14457).

语种：英文

外文关键词：Tachpleus tridentatus; plasma; peptide; nutritional appraisal; diabetes

外文摘要：Based on the bioactivities of blood protein, the nutritional appraisal and antidiabetic activity of a kind of mixed plasma proteolytic peptide from Tachpleus tridentatus (PPPT) were studied in this work. Results indicated that the amino acid level of PPPT could meet an adult's FAO/WHO recommended standard; PPPT also manifested inhibitory activity on alpha-glucosidase with IC50 at 2.62 mg/mL in vitro, and relieved symptoms of type II diabetic mouse in vivo by improving glucose tolerance, increasing insulin secretion by 5.15 mIU/L in the PPPT-4 group and by 4.54 mIU/L in the PPPT-1 group, reducing blood glucose values to nearly normal levels 120 min after intragastric administration, and restoring pathological damage in the thymus. Thus, PPPT can be developed into both a healthcare product and an adjuvant for type II diabetes in the future.