文献类型：期刊文献

英文题名：Preparation and evaluation of chitosan/salicylaldehyde/collagen peptide Schiff base hydrogels for wound healing

作者：Feng, Jinyuan[1,2];Cheng, Yu[1,2];Zhang, Baolong[4];Xie, Xinyi[4];Zheng, Chao[5];Huang, Yu[1,2,3];Jian, Jichang[1,2,3]

机构：[1]Guangdong Ocean Univ, Guangdong Prov Key Lab Aquat Anim Dis Control & Hl, Fisheries Coll, Zhanjiang 524088, Peoples R China;[2]Guangdong Higher Educ Inst, Key Lab Control Dis Aquat Anim, Zhanjiang 524088, Peoples R China;[3]Guangdong Prov Engn Res Ctr Aquat Anim Hlth Assess, Shenzhen, Peoples R China;[4]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[5]Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang 524088, Peoples R China

年份：2026

卷号：1352

外文期刊名：JOURNAL OF MOLECULAR STRUCTURE

收录：SCI-EXPANDED(收录号：WOS:001610601700002)、、WOS

基金：This work was funded by Guangdong Ocean University College Students' Innovation and Entrepreneurship Training Program (CXXL2025178) , the National Natural Science Foundation of China (No. 32073006, U20A2065) .

语种：英文

外文关键词：Chitosan; Schiff base; Wound healing

外文摘要：Hydrogels have emerged as highly promising wound dressing materials due to their similarity to the extracellular matrix and their ability to maintain a moist environment. In this study, we successfully synthesized a Schiff base-based chitosan/salicylaldehyde/collagen peptide (CS/SA/COP) hydrogel through the modification of chitosan (CS) with salicylaldehyde (SA) and subsequent reaction with fish collagen peptide (COP), aiming to enhance the hydrogel's wound healing properties. Structural characterization using scanning electron microscopy (SEM), ultraviolet spectroscopy (UV), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) confirmed the successful synthesis of the CS/SA/COP hydrogel. The hydrogel exhibits excellent water absorption and certain adhesion properties. In vitro hemolysis assays and cytotoxicity assays showed that CS/SA/COP hydrogels displayed excellent hemocompatibility and cytocompatibility. In vivo wound healing experiments revealed that after 15 days of treatment with the CS/SA/COP hydrogel, the wound healing rate reached 99.2 %, significantly outperforming both the chitosan group and the control group. In conclusion, the composite hydrogel developed in this study demonstrates substantial potential for application in the field of skin wound treatment.