文献类型：期刊文献

英文题名：Gastric acid-response chitosan/alginate/tilapia collagen peptide composite hydrogel: Protection effects on alcohol-induced gastric mucosal injury

作者：Lu, Sitong[1];Kong, Songzhi[1];Wang, Ye[1];Hu, Zhang[1];Zhang, Lingyu[1];Liao, Mingneng[1]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Dept Appl Chem, Zhanjiang 524088, Peoples R China

年份：2022

卷号：277

外文期刊名：CARBOHYDRATE POLYMERS

收录：SCI-EXPANDED(收录号：WOS:000720834400001)、、EI(收录号：20214411105118)、Scopus(收录号：2-s2.0-85118241507)、WOS

基金：The authors acknowledge the financial support of Guangdong Province of China (2016A030308009) and Project of Science and Technology Plan of Zhanjiang (2019A01017 and 2020A01026) , Project of Enhancing School with Innovation of Guangdong Ocean University (2017KTSCX090) , and Graduate Education Innovation Program of Guangdong Ocean University (201926) for this work

语种：英文

外文关键词：Hydrogels; Gastric acid-response; Alcohol-induced; Gastric mucosal injure

外文摘要：Long-term excessive alcohol intake can easily lead to gastritis, gastric ulcer, and gastric bleeding. In this paper, the gastric acid-responsive hydrogel of CS-NAC/alginate/tilapia collagen peptide (CS-NAC/ALG/TCP) was developed. Its structure and properties were determined. The alcohol-induced gastric mucosal injury models in mice were established to evaluate the protective effects of CS-NAC/ALG/TCP. The results showed that CS-NAC/ALG/TCP was successfully fabricated, and it showed a sustained release of TCP, strong mucoadhesion, and excellent biodegradability in vitro. In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues. It also down-regulated the expression of MPO, TNF-alpha, IL-1 beta, and IL-6, and increased the production of gastric protective factors such as PGE2 and NO in mouse stomach, thereby reducing the alcohol-induced inflammation and protecting the gastric mucosal injury. Besides, CS-NAC/ALG/TCP can also increase the activities of alcohol metabolism enzymes to improve alcohol metabolism, thereby reducing alcoholic damage. In conclusion, CS-NAC/ALG/TCP is a promising candidate for the treatment of alcohol-induced gastric injury.