文献类型：期刊文献

英文题名：The Complex Toxicity of Tetracycline with Polystyrene Spheres on Gastric Cancer Cells

作者：Yan, Xiemin[1];Zhang, Yuanyuan[2];Lu, Yuqin[3];He, Lei[3];Qu, Junhao[1,3];Zhou, Chunxia[1,2,4];Hong, Pengzhi[1,2,4];Sun, Shengli[3];Zhao, Hui[3,4];Liang, Yanqiu[3];Ren, Lei[5];Zhang, Yueqin[5];Chen, Jinjun[5];Li, Chengyong[2,3,4]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518108, Peoples R China;[3]Guangdong Ocean Univ, Sch Chem & Environm, Zhanjiang 524088, Peoples R China;[4]Southern Marine Sci & Engn Guangdong Lab Zhanjian, Zhanjiang 52088, Peoples R China;[5]Guangdong Ocean Univ, Coll Agr, Zhanjiang 24088, Peoples R China

年份：2020

卷号：17

期号：8

外文期刊名：INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH

收录：SSCI(收录号：WOS:000535744100193)、SCI-EXPANDED(收录号：WOS:000535744100193)、、Scopus(收录号：2-s2.0-85083990887)、WOS

基金：This research was funded by Guangdong Yangfan Program (201635018), Guangdong Special Support Program (2017TQ04N706), Science and Technology Planning Project of Zhanjiang City (2018A02014), Guangdong MEPP Fund (No. GDOE2019A52, R&D on Degradation of DL-PCBs and Microplastics Exposure to Microbes in South China Sea (Zhanjiang)), Industrial Development Special Funds of Dapeng New Area (KY20180202), Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang) (ZJW-2019-07, ZJW-2019-08), Innovation and Development Project about Marine Economy Demonstration of Zhanjiang City (2017C8B1), the Graduate Education Innovation Planning Project of Guangdong Ocean University (201924) and Training Programs of Innovation and Entrepreneurship for Undergraduates (CXXL2018008, CXXL2019302).

语种：英文

外文关键词：microplastics; nanoplastics; adsorption; tetracycline; AGS cells

外文摘要：Nowadays, microplastics (MPs) exist widely in the marine. The surface has strong adsorption capacity for antibiotics in natural environments, and the cytotoxicity of complex are poorly understood. In the study, 500 nm polystyrene (PS-MPs) and 60 nm nanoplastics (PS-NPs) were synthesized. The adsorption of PS to tetracycline (TC) was studied and their toxicity to gastric cancer cells (AGS) was researched. The adsorption experimental results show that PS absorbing capacity increased with increasing TC concentrations. The defense mechanism results show that 60 nm PS-NPs, 500 nm PS-MPs and their complex induce different damage to AGS cells. Furthermore, 600 mg/L PS-NPs and PS-MPs decline cell viability, induce oxidation stress and cause apoptosis. There is more serious damage of 60 nm PS-NPs than 500 nm PS-MPs in cell viability and intracellular reactive oxygen species (ROS). DNA are also damaged by 60 nm PS-NPs and PS-TC NPs, 500 nm PS-MPs and PS-TC MPs, and 60 nm PS-NPs damage DNA more serious than 500 nm PS-MPs. Moreover, 60 nm PS-NPs and PS-TC NPs seem to promote bcl-2 associated X protein (Bax) overexpression. All treatments provided us with evidence on how PS-NPs, PS-MPs and their compounds damaged AGS cells.