文献类型：期刊文献

英文题名：Single-Nucleus Rna Sequencing Reveals Regulatory Mechanisms of Bile Acids on Lipid Metabolism in Crustaceans

作者：Ma, Yuxuan[1]; Qu, Kangyuan[1]; Tan, Beiping[1,2,3]; Xie, Shiwei[1,2,3]

机构：[1] Laboratory of Aquatic Animal Nutrition and Feed, Fisheries College, Guangdong Ocean University, Zhanjiang, China; [2] Key Laboratory of Aquatic Feed Science and Technology for Livestock and Poultry in Southern China, under the Ministry of Agriculture, Zhanjiang, China; [3] Key Laboratory of Control for Disease of Aquatic Animals of Guangdong Higher Education Institutes, Zhanjiang, China

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250310820)

语种：英文

外文关键词：Body fluids - Cell proliferation - Diseases - Lipids - Metabolism - Physiology

外文摘要：Bile acids participate in the absorption and emulsification of lipids during lipid metabolism, liver serving as the primary site for their regulatory functions. Crustaceans lack the capacity for de novo synthesis of bile acids and potentially exhibit significant differences in bile acid metabolic utilization mechanisms compared to vertebrates. This study employed Litopenaeus vannamei as a model organism to investigate the role of bile acids in crustaceans' lipid metabolism by establishing high- and low-fishmeal control groups and a bile acid supplementation group (400 mg/kg). Hepatopancreatic histomorphological and biochemical analyses revealed that bile acid supplementation significantly ameliorated inflammatory responses and fibrosis in the hepatopancreas (P ? 2025, The Authors. All rights reserved.