文献类型：期刊文献

英文题名：The roles of sugar metabolism mechanisms and metabolites in viral infections

作者：He, Jieyi[1];Ju, Xianghong[1,2];Abd El-Aty, A. M.[3,4];Liu, Xiaoxi[1];Li, Xiaowen[1]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Marine Med Res & Dev Ctr, Shenzhen Inst, Shenzhen 518120, Peoples R China;[3]Cairo Univ, Fac Vet Med, Dept Pharmacol, Giza 12211, Egypt;[4]Ataturk Univ, Med Fac, Dept Med Pharmacol, TR-25240 Erzurum, Turkiye

年份：2026

卷号：615

外文期刊名：VIROLOGY

收录：SCI-EXPANDED(收录号：WOS:001632844600001)、、WOS

基金：Funding This work was funded by Guangdong Major Project of Basic and Applied Basic Research (No. 2023B0303000014) , the Postdoctoral Fellowship Program of CPSF (No. GZC20251983) and Youth S & T Talent Support Programme of Guangdong Provincial Association for Science and Technology (No. SKXRC2025393) .

语种：英文

外文关键词：Glycolysis; Viral infection; Metabolic reprogramming; Antiviral therapy

外文摘要：Viral infections pose a persistent challenge to global health by triggering sophisticated molecular interactions and extensive metabolic reprogramming within host organisms. Glycolysis-a central energy metabolism pathway-is dynamically and bidirectionally regulated during infection, reflecting a continuous metabolic interplay between pathogen and host. Rather than maintaining a static metabolic state, glycolytic flux is shaped by competing demands: viruses actively stimulate glycolysis to support replication, while hosts suppress it as a defensive strategy. This regulatory balance shifts across distinct stages of infection-from viral entry and replication peaks to immune clearance-resulting in phase-specific fluctuations in glycolytic activity that reveal a dynamic metabolic tug-of-war. In this review, we synthesize current understanding of how viruses recurrently activate host glycolysis to enhance replication, detailing conserved mechanisms of metabolic hijacking and the multilayered counterstrategies employed by the host. We further evaluate emerging therapeutic approaches, including targeted glycolytic inhibitors and combined immunomodulatory regimens, while addressing challenges related to specificity and efficacy. Finally, we highlight promising research directions such as tissuespecific nanodelivery platforms and single-cell multi-omics integration, which together offer a conceptual framework for developing next-generation antiviral therapies.