文献类型：期刊文献

英文题名：Molecular Targets and Related Biologic Activities of Fucoidan: A Review

作者：Lin, Zhen[1];Tan, Xiaohui[1];Zhang, Yu[1];Li, Fangping[1];Luo, Ping[1];Liu, Huazhong[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China

年份：2020

卷号：18

期号：8

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000564050200001)、、Scopus(收录号：2-s2.0-85088675220)、WOS

基金：This work was supported by the Natural Science Foundation of Guangdong Province, China (2019A1515011102), and the Science and Technology Project on Special Fund for Public Welfare Research and Ability Construction of Guangdong Province, China (2017A010105010).

语种：英文

外文关键词：fucoidan; molecular target; biologic activity

外文摘要：Fucoidan-a marine natural active polysaccharide derived from brown algae with a variety of medicinal activities and low toxicity-has been used as clinical drug for renal diseases for nearly 20 years. The pharmacological mechanism of fucoidan has been well-investigated, based on target molecules and downstream signaling pathways. This review summarizes some important molecular targets of fucoidan and its related biologic activities, including scavenger receptor (SR), Toll-like receptors (TLRs), C-type lectin (CLEC) and some newly found target molecules, which may be beneficial for further understanding the pharmacological mechanism of fucoidan and discovering its new functions, as well as developing related clinical or adjuvant drugs and functional preparations.