文献类型：期刊文献

英文题名：Water Extract of Chrysanthemum indicum L. Flower Inhibits Capsaicin-Induced Systemic Low-Grade Inflammation by Modulating Gut Microbiota and Short-Chain Fatty Acids

作者：Yang, Bing[1];Sun, Dongfang[2];Sun, Lijun[1];Cheng, Yaokun[1];Wang, Chen[1];Hu, Lianhua[1];Fang, Zhijia[1];Deng, Qi[1];Zhao, Jian[3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[2]Nanjing Agr Univ, Coll Food Sci & Technol, Natl Ctr Meat Qual & Safety Control, Nanjing 210095, Peoples R China;[3]Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia

年份：2023

卷号：15

期号：5

外文期刊名：NUTRIENTS

收录：SCI-EXPANDED(收录号：WOS:000947534100001)、、Scopus(收录号：2-s2.0-85149715750)、WOS

基金：This research was funded by the Guangdong Provincial Special Fund for Modern Agricultural Industry Technology Innovation Teams [2022KJ149, 2022KJ151]. Guangdong Provincial key research and development program (2021B0202060001).

语种：英文

外文关键词：systemic low-grade inflammation; capsaicin; Chrysanthemum indicum L; gut microbiota; short-chain fatty acid

外文摘要：Systemic low-grade inflammation induced by unhealthy diet has become a common health concern as it contributes to immune imbalance and induces chronic diseases, yet effective preventions and interventions are currently unavailable. The Chrysanthemum indicum L. flower (CIF) is a common herb with a strong anti-inflammatory effect in drug-induced models, based on the theory of "medicine and food homology". However, its effects and mechanisms in reducing food-induced systemic low-grade inflammation (FSLI) remain unclear. This study showed that CIF can reduce FSLI and represents a new strategy to intervene in chronic inflammatory diseases. In this study, we administered capsaicin to mice by gavage to establish a FSLI model. Then, three doses of CIF (7, 14, 28 g center dot kg(-1)center dot day(-1)) were tested as the intervention. Capsaicin was found to increase serum TNF-alpha levels, demonstrating a successful model induction. After a high dose of CIF intervention, serum levels of TNF-alpha and LPS were reduced by 62.8% and 77.44%. In addition, CIF increased the alpha diversity and number of OTUs in the gut microbiota, restored the abundance of Lactobacillus and increased the total content of SCFAs in the feces. In summary, CIF inhibits FSLI by modulating the gut microbiota, increasing SCFAs levels and inhibiting excessive LPS translocation into the blood. Our findings provided a theoretical support for using CIF in FSLI intervention.