文献类型：期刊文献

英文题名：Enhancement of bioavailability and bioactivity of diet-derived flavonoids by application of nanotechnology: a review

作者：Teng, Hui[1];Zheng, Yimei[1];Cao, Hui[1];Huang, Qun[2,3];Xiao, Jianbo[4,5];Chen, Lei[1]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang, Peoples R China;[2]Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang, Peoples R China;[3]Chengdu Univ, Sch Food & Biol Engn, Meat Proc Key Lab Sichuan Prov, Chengdu, Peoples R China;[4]Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang, Jiangsu, Peoples R China;[5]Univ Vigo, Fac Food Sci & Technol, Dept Analyt Chem & Food Sci, Vigo, Spain

年份：0

外文期刊名：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

收录：SCI-EXPANDED(收录号：WOS:000674777800001)、、EI(收录号：20213010672769)、Scopus(收录号：2-s2.0-85110865201)、WOS

基金：This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 32072209, Grant No. 31801459); China Postdoctoral Science Foundation Funded Project (2020M682073); Science and Technology General Projects of Fujian Province (2019J01393).

语种：英文

外文关键词：Absorption; anti-cancer; antioxidant; flavonoid; health benefit; nanoformulation

外文摘要：Flavonoids, which are a class of polyphenols widely existing in food and medicine, have enormous pharmacological effects. The functional properties of flavonoids are mainly distributed to their anti-oxidative, anticancer, and anti-inflammatoryeffects, etc. However, flavonoids' low bioavailability limits their clinical application, which is closely related to their intestinal absorption and metabolism. In addition, because of the short residence time of oral bioactive molecules in the stomach, low permeability and low solubility in the gastrointestinal tract, flavonoids are easy to be decomposed by the external environment and gastrointestinal tract after digestion. To tackle these obstacles, technological approaches like microencapsulation have been developed and applied for the formulation of flavonoid-enriched food products. In the light of these scientific advances, the objective of this review is to establish the structural requirements of flavonoids for appreciable anticancer, anti-inflammatory, and antioxidant effects, and elucidate a comprehensive mechanism that can explain their activity. Furthermore, the novelty in application of nanotechnology for the safe delivery of flavonoids in food matrices is discussed. After a literature on the flavonoids and their health attributes, the encapsulation methods and the coating materials are presented.