文献类型：期刊文献

英文题名：Modified chitosan/oxidized carrageenan composite hydrogels incorporated with sea cucumber protein peptides as a potential novel biomedical material

作者：Dong, Hongrui[1];Huang, Jinhong[1];Li, Chengpeng[1];Pang, Mengyuan[1];Hu, Zhang[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China

年份：2026

卷号：365

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001766337600001)、、EI(收录号：20262020726556)、Scopus(收录号：2-s2.0-105038866005)、WOS

基金：The authors acknowledge the financial support of Guangdong Pro-vincial Natural Science Foundation of China (2024A1515012618 and 2026A1515010006) , Key Projects of Colleges and Universities in Guangdong Province (2022ZDZX2027) , and Zhanjiang Science and Technology Plan Project (2021A05041) .

语种：英文

外文关键词：Chitosan; Carrageenan; Hydrogel; Antibacterial

外文摘要：Facing the challenges of bacterial infection and antibiotic resistance, the development of biomaterials with both excellent antibacterial properties and biocompatibility is of great significance. Using chitosan (CS) and kappa-carrageenan (Car) as raw materials, tris(hydroxymethyl)methylglycine-modified chitosan (CS-TMG) and oxidized carrageenan (O-Car) were respectively synthesized. And then by incorporating sea cucumber protein peptides (SPH), a multi-network CS-TMG/O-Car/SPH hydrogel was successfully prepared. Characterization by UV, FTIR, 1H NMR, XPS and XRD confirmed the successful grafting of TMG onto CS, the formation of aldehyde groups in Car, and the network structure stabilized by dynamic imine bonds and multiple physical interactions. CS-TMG/O-Car/SPH hydrogel exhibited a lamellar porous morphology and a high swelling ratio (2199%), coupled with good self-healing properties, injectability, and sustained-release characteristics (73.12% of SPH cumulative release within 72 h). Antibacterial tests revealed that CS-TMG/O-Car/SPH possessed significant antibacterial activities against both Staphylococcus aureus and Escherichia coli. Assessment of the biosafety revealed that CS-TMG/O-Car/SPH had a low hemolysis rate and negligible cytotoxicity, showing excellent biocompatibility. Consequently, CS-TMG/O-Car/SPH hydrogel is a promising candidate as an antibacterial biomaterial in the fields of wound healing and tissue engineering.