文献类型：期刊文献

英文题名：Synthesis, characterization and potential applications for oxidized agarose

作者：Li, Chengpeng[1];Li, Xianzhu[1,2];Gu, Qixiang[1,2];Xie, Lici[1];Cai, Ying[1];Liao, Lusheng[2,3]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China;[3]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Guangdong Prov Key Lab Nat Rubber Proc, Zhanjiang 524001, Peoples R China

年份：2023

卷号：242

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001001335100001)、、EI(收录号：20242616341337)、Scopus(收录号：2-s2.0-85156198256)、WOS

基金：This work was financially supported by Natural Science Foundation of Guangdong Province, P.R.C (2020A1515011011), Project of Zhanjiang Science & Technology Plan (2022A01025), Foundation of Guangdong Provincial Key Laboratory of Natural Rubber Processing, P. R. China, Guangdong Postgraduate Joint Training Base.

语种：英文

外文关键词：Agarose; Gelling temperature; Cytocompatibility

外文摘要：The knowledge of agarose (AG) oxidation using periodate as oxidizer has not been systematically explored. This paper synthesized oxidized agarose (OAG) using solid-sate and solution reaction methods; the reaction mecha-nism and the properties of OAG samples were systematically evaluated. Chemical structure analysis disclosed that the aldehyde group and carboxyl group contents in all OAG samples are extremely low. Meanwhile, crys-tallinity, dynamic viscosity and molecular weight of OAG samples is lower than that of the original AG. Reaction temperature, time and sodium periodate dosage are inversely proportional to the decline of the gelling tem-perature (Tg) and melting temperature (Tm); and the Tg and Tm for the OAG sample obtained are even 19 degrees C and 22 degrees C lower than that of the original AG. The as-synthesized OAG samples all possess excellent cytocompatibility and blood compatibility; and can promote the proliferation and migration of fibroblast cells. Last but not least, the gel strength, hardness, cohesiveness, springiness and chewiness of the OAG gel can be effectively regulated via oxidation reaction. In conclusions, both solid and solution oxidation can regulate the physical properties of OAG and enlarge its potential applications in wound dressing, tissue engineering and food areas.