文献类型：期刊文献

英文题名：Carboxymethyl pachymaran attenuates short-term stress induced depressive behaviours and over-expression of occludin and claudin-2 in the blood-brain-barrier by regulating inflammatory cytokines- JNK/ERK/p38 pathway

作者：He, Jiatao[1];Hu, Lianhua[1];Deng, Qi[1,3];Sun, Lijun[1,3];Zhao, Yuntao[1];Fang, Zhijia[1];Wang, Chen[1];Zhao, Jian[2]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Guangdong, Peoples R China;[2]Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia;[3]Guangdong Ocean Univ, 1 Haidao Rd, Zhanjiang 524088, Guangdong, Peoples R China

年份：2023

卷号：103

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：SCI-EXPANDED(收录号：WOS:000951640000001)、、Scopus(收录号：2-s2.0-85150869049)、WOS

基金：Fundings This work was supported by grants from the Guangdong Provincial Special Fund for Modern Agricultural Industry Technology Innovation Teams [2022KJ149, 2022KJ151] . Guangdong Provincial key research and development program (2021B0202060001) .

语种：英文

外文关键词：Inflammation; Short-term stress; Carboxymethyl pachymaran; Blood-brain barrier; Tight junction proteins

外文摘要：The present study aimed to investigate the protective effect of carboxymethyl pachymaran (CMP) on the short-term stress mice model. The behavioural tests revealed the CMP treatment can improve depression-like behaviour in the mice model. Short-term stress induced over-expression of occludin and claudin-2 proteins in the blood-brain barrier (BBB) was significantly reversed by CMP through regulation of the inflammatory cytokines-JNK/ERK/P38 pathway. Systemic inflammation caused by short-term stress was suppressed by CMP treatment through increasing concentrations of propionic, and valeric acids, and decreasing isovaleric acid concentrations in the feces. In addition, CMP elevated the levels of hippocampal 5-hydroxytryptamine (5-HT) and norepinephrine (NE). In conclusion, CMP attenuates depression-like behaviours caused by short-term stress, which may be associated with mediating the short-chain fatty acids (SCFAs)-inflammatory cytokines-ERK/JNK/ p38 pathway to down-regulate the expression of occludin and claudin-2 proteins in the BBB, and also may be related to elevated levels of NE and 5-HT in the hippocampus.