文献类型：期刊文献

中文题名：鲎血蛋白壳寡糖-透明质酸微球的制备及其活性分析

英文题名：Preparation and Activity Analysis of Chitosan Oligosaccharide-hyaluronic Acid Microspheres with Blood Protein from Tachypleus Tridentatus

作者：王耀祺[1];蔡鹰[1];康信煌[1];邓春梅[1];吴育廉[1];张国光[1]

机构：[1]广东海洋大学化学与环境学院,广东湛江524088

年份：2020

卷号：47

期号：12

起止页码：113

中文期刊名：云南化工

外文期刊名：Yunnan Chemical Technology

基金：国家级大学生创新创业训练计划项目(201910566028)。

语种：中文

中文关键词：鲎血蛋白;微球;α-葡萄糖苷酶;乙酰胆碱酯酶

外文关键词：blood protein of Tachypleus Tridentatus;microspheres;α-glucosidase;acetylcholinesterase

中文摘要：以壳寡糖、透明质酸为原料包载鲎血蛋白,考察包载不同分子量鲎血蛋白的微球对α-葡萄糖苷酶、乙酰胆碱酯酶的相关活性。结果表明鲎血蛋白壳寡糖-透明质酸微球表面较为规整,平均粒径为(3.11±0.42)μm,包封率为(60.57±0.52)%,载药量为(63.02±2.13)%,pH6.8磷酸盐缓冲液中12h的累积释放率为46.23%。三种载药微球对乙酰胆碱酯酶都具有良好的抑制活性。

外文摘要：COS-HA microspheres with blood protein were prepared from COS and HA.The related activities of the microspheres containing different molecular weight blood protein on α-glucosidase and acetylcholin esterase were investigated.Result has shown that the microspheres of COS-HA microspheres with blood protein were with a relatively regular surface.The average particle size was(3.11±0.42)μm,encapsulation rate of(60.57±0.52)%,drug loading of(63.02±2.13)%and cumulative release rate of pH6.8 phosphate buffer was 46.23%after 12 h.The three drug-loaded microspheres all had good inhibitory activities on acetylcholin esterase.