文献类型：期刊文献

英文题名：Influence of Heat Stress on Intestinal Epithelial Barrier Function, Tight Junction Protein, and Immune and Reproductive Physiology

作者：Ghulam Mohyuddin, Sahar[1,2];Khan, Imran[3];Zada, Ahmad[3];Qamar, Aftab[2];Arbab, Abdelaziz Adam Idriss[1];Ma, Xin-bing[4];Yu, Zhi-chao[4];Liu, Xiao-Xi[4];Yong, Yan-Hong[4];Ju, Xiang Hong[4];Zhang-Ping, Yang[1];Yong Jiang, Mao[1]

机构：[1]Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China;[2]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Anim Sci, Zhanjiang 524088, Guangdong, Peoples R China;[3]Yangzhou Univ, Coll Biosci & Biotechnol, Yangzhou 225009, Peoples R China;[4]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Vet Med, Zhanjiang 524088, Guangdong, Peoples R China

年份：2022

卷号：2022

外文期刊名：BIOMED RESEARCH INTERNATIONAL

收录：SCI-EXPANDED(收录号：WOS:000867858500001)、、Scopus(收录号：2-s2.0-85137691941)、WOS

基金：AcknowledgmentsWe would like to acknowledge all of our colleagues who helped us in writing this manuscript. This study was supported by the National Natural Science Foundation of China (31972555) and Natural Science Research Project of Colleges and Universities in Jiangsu Province.

语种：英文

外文摘要：The potential threat of global warming in the 21(st) century is on the ecosystem through many aspects, including the negative impact of rising global temperature on the health of humans and animals, especially domestic animals. The damage caused by heat stress to animals has been more and more significant as the worldwide climate continues to rise, along with the breeding industry's expanding scale and stocking density, and it has become the most important stress-causing factor in southern China. In this review, we described the effects of heat stress on animal immune organs and immune system. The much-debated topic is how hyperthermia affects the tight junction barrier. Heat stress also induces inflammation in the body of animals causing low body weight and loss of appetite. This review also discussed that heat stress leads to hepatic disorder, and it also damages the intestine. The small intestine experiences ischemia, and the permeability of the intestine increases. Furthermore, the oxidative stress and mitogen-activated protein kinase (MAPK) pathways have a significant role in stress-induced cellular and organ injury. The study has shown that MAPK activity in the small intestine was increased by heat stress. Heat stress caused extreme small intestine damage, enhanced oxidative stress, and activated MAPK signaling pathways.