文献类型：期刊文献

英文题名：Zebrafish neurobehavioral phenomics for aquatic neuropharmacology and toxicology research

作者：Kalueff, Allan V.[1,2,3,4,10,11];Echevarria, David J.[2,5];Homechaudhuri, Sumit[6];Stewart, Adam Michael[2,3];Collier, Adam D.[2,5];Kaluyeva, Aleksandra A.[3];Li, Shaomin[1];Liu, Yingcong[1];Chen, Peirong[1];Wang, JiaJia[1];Yang, Lei[1];Mitra, Anisa[6];Pal, Subharthi[6];Chaudhuri, Adwitiya[6];Roy, Anwesha[6];Biswas, Missidona[6];Roy, Dola[6];Podder, Anupam[6];Poudel, Manoj K.[2,3];Katare, Deepshikha P.[7];Mani, Ruchi J.[7];Kyzar, Evan J.[2,8];Gaikwad, Siddharth[9];Michael Nguyen[2,3];Song, Cai[1,9]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Res Inst Marine Drugs & Nutr, Zhanjiang 524025, Guangdong, Peoples R China;[2]Int Zebrafish Neurosci Res Consortium ZNRC, Slidell, LA 70458 USA;[3]ZENEREI Inst, 309 Palmer Court, Slidell, LA 70458 USA;[4]St Petersburg State Univ, Inst Translat Biomed, St Petersburg 199034, Russia;[5]Univ So Mississippi, Dept Psychol, 118 Coll Dr, Hattiesburg, MS 39406 USA;[6]Univ Calcutta, Dept Zool, 35 Ballygunge Circular Rd, Kolkata 700019, W Bengal, India;[7]Am Univ Uttar Pradesh, Am Inst Biotechnol, Ctr Med Biotechnol, Prote & Translat Res Lab, Noida 201303, UP, India;[8]Univ Illinois, Inst Psychiat, Dept Psychiat, 1601 W Taylor St, Chicago, IL 60612 USA;[9]China Med Univ Hosp, Grad Inst Neural & Cognit Sci, Taichung 40402, Taiwan;[10]Ural Fed Univ, Inst Chem Technol, Ekaterinburg 620002, Russia;[11]Ural Fed Univ, Inst Nat Sci, Ekaterinburg 620002, Russia

年份：2016

卷号：170

起止页码：297

外文期刊名：AQUATIC TOXICOLOGY

收录：SCI-EXPANDED(收录号：WOS:000368564500032)、、Scopus(收录号：2-s2.0-84952637400)、WOS

基金：This study is coordinated by the International Zebrafish Neuroscience Research Consortium (ZNRC), and supported by ZENEREI Institute, Guangdong Ocean University (GDOU) and the University of Calcutta. A.V.K. is the Chair of ZNRC.

语种：英文

外文关键词：Zebrafish; Aquatic model; Neurophenomics; Neuropsychopharmacology; Ecotoxicology; Behavior

外文摘要：Zebrafish (Danio rerio) are rapidly emerging as an important model organism for aquatic neuropharmacology and toxicology research. The behavioral/phenotypic complexity of zebrafish allows for thorough dissection of complex human brain disorders and drug-evoked pathological states. As numerous zebrafish models become available with a wide spectrum of behavioral, genetic, and environmental methods to test novel drugs, here we discuss recent zebrafish phenomics methods to facilitate drug discovery, particularly in the field of biological psychiatry. Additionally, behavioral, neurological, and endocrine endpoints are becoming increasingly well-characterized in zebrafish, making them an inexpensive, robust and effective model for toxicology research and pharmacological screening. We also discuss zebrafish behavioral phenotypes, experimental considerations, pharmacological candidates and relevance of zebrafish neurophenomics to other 'omics' (e.g., genomic, proteomic) approaches. Finally, we critically evaluate the limitations of utilizing this model organism, and outline future strategies of research in the field of zebrafish phenomics. (C) 2015 Elsevier B.V. All rights reserved.