文献类型：期刊文献

英文题名：Oleic Acid Facilitates Cd Excretion by Increasing the Abundance of Burkholderia in Cd-Exposed Mice

作者：Fang, Zhijia[1,2,3,4];Chen, Yinyan[1,2,3,4];Li, Yongbin[1,2,3,4];Sun, Lijun[1,2,3,4];Deng, Qi[1,2,3,4];Wang, Jingwen[1,2,3,4];Gooneratne, Ravi[5]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[2]Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[3]Guangdong Prov Engn Technol Res Ctr Marine Food, Zhanjiang 524088, Peoples R China;[4]Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Zhanjiang 524088, Peoples R China;[5]Lincoln Univ, Dept Wine Food & Mol Biosci, Canterbury 7647, New Zealand

年份：2022

卷号：23

期号：23

外文期刊名：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

收录：SCI-EXPANDED(收录号：WOS:000896236100001)、、WOS

基金：This work was supported by the National Natural Science Foundation of China (No. 32172215 and 31701706), the Natural Science Foundation of Guangdong Province (No. 2019A1515010809 and 2021A1515012443), and the Characteristic Innovation Project of Guangdong Province (No. 2018KTSCX089).

语种：英文

外文关键词：cadmium accumulation; cadmium excretion; oleic acid; gut microbiota; Burkholderia cepacia; extracellular polymeric substances

外文摘要：As a global pollutant, cadmium (Cd) can easily enter the body through food chains, threatening human health. Most Cd is initially absorbed in the gut, with the gut microbiota playing a pivotal role in reducing Cd absorption and accumulation. This study assessed the effects of three fatty acids on Cd accumulation and toxicity in Cd-exposed mice. The results showed that oleic acid (OA) was the most effective in facilitating Cd excretion in mice among these fatty acids. The use of OA led to reduced Cd accumulation in the organs and increased Cd content in the feces. The metagenomic analysis of the gut microbiota showed that the genus Burkholderia was the most significantly restored by OA in Cd-exposed mice. Burkholderia cepacia, as the type species for the genus Burkholderia, also exhibited strong Cd tolerance after treatment with OA. Furthermore, the electron microscopy analysis showed that most of the Cd was adsorbed on the surface of B. cepacia, where the extracellular polymeric substances (EPSs) secreted by B. cepacia play a key role, displaying a strong capacity for Cd adsorption. The peak at 2355 cm(-1) and the total sulfhydryl group content of EPSs showed significant increases following co-treatment with Cd and OA. The results demonstrated the potential roles that gut Burkholderia may play in OA-mediated Cd excretion in mice.