文献类型：期刊文献

英文题名：Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in Vertebrates

作者：Wang, Bei[1,2];Wangkahart, Eakapol[2,3];Secombes, Christopher J.[2];Wang, Tiehui[2]

机构：[1]Guangdong Ocean Univ, Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Key Lab Control Dis Aquat Anim, Guangdong Higher Educ Inst,Coll Fishery, Zhanjiang, Peoples R China;[2]Univ Aberdeen, Inst Biol & Environm Sci, Scottish Fish Immunol Res Ctr, Aberdeen, Scotland;[3]Mahasarakham Univ, Res Unit Excellence Trop Fisheries & Technol, Div Fisheries, Dept Agr Technol,Fac Technol, Kantarawichai, Mahasarakham, Thailand

年份：2019

卷号：36

期号：2

起止页码：393

外文期刊名：MOLECULAR BIOLOGY AND EVOLUTION

收录：SCI-EXPANDED(收录号：WOS:000459328600014)、、Scopus(收录号：2-s2.0-85061502017)、WOS

基金：This study was supported by the National Natural Science Foundation of China (Grant No. 31702386), International Cooperation Science & Technology Planning Project of Guangdong Province of China (Grant No. 2017A050501037). E.W. was supported financially by the Ministry of Science and Technology of Thailand and Mahasarakham University. T.W. received funding from the Marine Alliance for Science and Technology for Scotland (MASTS), a pooling initiative funded by the Scottish Funding Council (grant reference HR09011).

语种：英文

外文关键词：rainbow trout; SOCS gene family; synteny; phylogenetic tree; whole genome duplication; evolution; gene expression; ontogeny; cytokine and growth factor signaling

外文摘要：The SOCS family are key negative regulators of cytokine and growth factor signaling. Typically, 8-17 SOCS genes are present in vertebrate species with eight known in mammals, classified as type I (SOCS4-7) and type II (CISH and SOCS1-3) SOCS. It was believed that the type II SOCS were expanded through the two rounds of whole genome duplication (1R and 2R WGDs) from a single CISH/SOCS1-3 precursor. Previously, 12 genes were identified in rainbow trout but here we report 15 additional loci are present, and confirm 26 of the genes are expressed, giving rainbow trout the largest SOCS gene repertoire identified to date. The discovery of the additional SOCS genes in trout has led to a novel model of SOCS family evolution, whereby the vertebrate SOCS gene family was derived from CISH/SOCS2, SOCS1/SOCS3, SOCS4/5, SOCS6, and SOCS7 ancestors likely present before the two WGD events. It is also apparent that teleost SOCS2b, SOCS4, and SOCS5b molecules are not true orthologues of mammalian SOCS2, SOCS4, and SOCS5, respectively. The rate of SOCS gene structural changes increased from 2R vertebrates, to 4R rainbow trout, and the genes with structural changes show large differences and low correlation coefficient of expression levels relative to their paralogues, suggesting a role of structural changes in expression and functional diversification. This study has important impacts in the functional prediction and understanding of the SOCS gene family in different vertebrates, and provides a framework for determining how many SOCS genes could be expected in a particular vertebrate species/lineage.