文献类型：期刊文献

中文题名：盐酸氯苯胍在眼斑拟石首鱼体内的药代动力学和残留消除规律研究

英文题名：Pharmacokinetics and Elimination of Robenidine Hydrochloride Residues in Red Drum Sciaenops ocellatus

作者：汤菊芬[1,2];黄瑜[1,2];蔡佳[1,2];廖建萌[3];黄月雄[1,2];简纪常[1,2]

机构：[1]广东海洋大学水产学院,广东湛江524088;[2]广东省水产经济动物病原生物学及流行病学重点实验室,广东湛江524088;[3]广东省湛江市质量计量监督检测所,广东湛江524022

年份：2017

卷号：36

期号：4

起止页码：493

中文期刊名：水产科学

外文期刊名：Fisheries Science

收录：CSTPCD、、北大核心2014、CSCD_E2017_2018、北大核心、CSCD

基金：农业部公益性行业专项(20120385);广东省科技计划(农村科技领域)项目(2015A020209181)

语种：中文

中文关键词：盐酸氯苯胍;眼斑拟石首鱼;药代动力学;残留消除

外文关键词：robenidine hydrochloride; Sciaenops ocellatus; pharmacokinetics; residue

中文摘要：在水温(28±2)℃、盐度28条件下,采用30mg/kg的剂量口灌法,用HPLC-MS/MS检测研究了盐酸氯苯胍在体质量为(350.15±5.18)g的眼斑拟石首鱼体内的药代动力学和残留消除规律。结果显示,单剂量口灌给药后,眼斑拟石首鱼血浆中盐酸氯苯胍的药时数据符合一级吸收二室模型,药物在血浆中的达峰时间、血药质量浓度峰值、药时曲线下面积和消除半衰期分别为2.39h、958.78μg/L、33 247.57μg/(L·h)和19.24h;盐酸氯苯胍在肌肉、肝脏和肾脏的血药含量峰值分别为156.72、227.68μg/kg和553.44μg/kg,达峰时间分别为2.0、1.5、2.0h;药时曲线下面积分别4664.04、4897.74、17 228.19μg/(kg·h);消除半衰期分别为19.68、24.33、22.81h。按30mg/kg剂量连续5d口灌给药后,鱼血浆、肌肉、肝脏、肾脏中的药物消除半衰期(t1/2)分别为24.46、35.39、39.60、33.94h。若以10μg/kg为最高残留限量,肌肉作为食用靶组织,在本试验条件下,建议休药期不少于7d。

外文摘要：The pharmacokinetics and elimination regularity of robenidine hydrochloride（ROBH）residues were investigated in plasma and tissues of red drumSciaenops ocellatus with body weight of（350.15±5.18）g orally administrated at a single dose of 30 mg/kg body weight at water temperature of（28±2）℃and salinity of 28 by HPLC-MS/MS method.Results showed that ROBH concentration-time data in plasma of red drum was described as a two-compartment model with first-order absorption after a single dose of oral administration,with the peak time（tp）of 2.39 h,the maximum concentration（Cmax）of 958.78 μg/L,the area under the concentration-time curve（AUC0—∞）of 33 247.57 μg/（L·h）and the elimination hal-life（tl/2β）of 19.24 hin plasma.The findings indicated that ROBH in red drum had the ability to be distributed widely in diverse tissues and that ROBH residues were eliminated slowly.The Cmax was found to be 156.72 μg/kg in muscle,227.68 μg/kg in liver and 553.44 μg/kg in kidney,and tpwas 2.0 hin muscle,1.5 hin liver and 2.0 hin kidney.AUC0—∞ were shown to be 4664.04 μg/（kg·h）in muscle,4897.74 μg/（kg·h）in liver and 17 228.19 μg/（kg·h）in kidney,with tl/2β of 19.68 hin muscle,24.33 hin liver and 22.81 hin kidney.The t 1/2 was 24.46 hin plasma,35.39 hin muscle,39.60 hin liver and 33.94 hin kidney in red drum with oral continuous administration at a dose of 30 mg/kg for 5 days.If the maximum residue limits（MRLs）was considered as 0.01 mg/kg and the muscles as edible target tissue,the withdrawl period should be over 7 days under this experiment condition.