文献类型：期刊文献

英文题名：Determining the potent immunostimulation potential arising from the heteropolysaccharide structure of a novel fucoidan, derived from Sargassum Zhangii

作者：Li, Rui[1,4];Zhou, Qing-Ling[1];Yang, Rui-Yu[1];Chen, Shu-Tong[1,5];Ding, Rui[2];Liu, Xiao-Fei[1];Luo, Lian-Xiang[2];Xia, Qiu-Yu[1];Zhong, Sai-Yi[1,4];Qi, Yi[2];Williams, Richard J.[3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Marine Food, Guangdong Prov Sci & Technol Innovat Ctr Subtrop F, Zhanjiang 524008, Guangdong, Peoples R China;[2]Guangdong Med Univ, Marine Biomed Res Inst, Marine Biomed Res Inst Guangdong Zhanjiang, Zhanjiang 524023, Peoples R China;[3]Deakin Univ, Sch Med, IMPACT, Waurn Ponds, Vic 3217, Australia;[4]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China;[5]Shantou Univ, Coll Sci, Dept Biol, Shantou 515063, Peoples R China

年份：2023

卷号：18

外文期刊名：FOOD CHEMISTRY-X

收录：SCI-EXPANDED(收录号：WOS:001003826000001)、、EI(收录号：20232114120854)、Scopus(收录号：2-s2.0-85159554414)、WOS

基金：This work was supported in part by the General Project of Natural Science Foundation of Guangdong Province (2021A1515010868) , the National Natural Science Foundation of China (32172252) , the Guangdong Province Ordinary Universities Characteristic Innovation Project (2020KTSCX051) , the Innovative Team Program of High Education of Guangdong Province (2021KCXTD021) , Innovative Training program for college students of Guangdong Ocean University (S202210566016) , the Open Project of Key Laboratory of Functional Food of Ministry of Agriculture (202107) , the National Key Research and Development Project (2020YFD0901101) , and the Doctoral Research Initiation Project of Guangdong Ocean University (R20078, R19017) . We appreciate Professor Ri-Ming Huang and postgraduate student Yu-Qi Lin for the NMR data processing. We thank the Public Service Platform of South China Sea for R & D Marine Biomedicine Resources for support, and we also thank Sanshu Biotechnology for its analysis of NMR data.

语种：英文

外文关键词：Brown algae; Polysaccharide; Immunomodulatory activities; Structural characterization

外文摘要：A preliminary study was conducted of the chemical, structural properties and immunomodulatory activities of fucoidan isolated from Sargassum Zhangii (SZ). Sargassum Zhangii fucoidan (SZF) was determined to have a sulfate content of 19.74 +/- 0.01% (w/w) and an average molecular weight of 111.28 kDa. SZF possessed a backbone structure of (1,4)-alpha-D-linked-galactose, (3,4)-alpha-L-fucose, (1,3)-alpha-D-linked-xylose, beta-D-linked-mannose and a terminal (1,4)-alpha-D-linked-glucose. The main monosaccharide composition was determined as (w/w) 36.10% galactose, 20.13% fucose, 8.86% xylose, 7.36% glucose, 5.62% mannose, and 18.07% uronic acids, respectively. An immunostimulatory assay showed that SZF, compared to commercial fucoidans (Undaria pitnnaifida and Fucus vesiculosus sources), significantly elevated nitric oxide production via up-regulation of cyclooxygenase-2 and inducible nitric oxide synthase at both gene and protein levels. These results suggest that SZ has the potential to be a source of fucoidan with enhanced properties that may act as a useful ingredient for functional foods, nutritional supplements, and immune enhancers.