文献类型：期刊文献

英文题名：A peptide isolated from Hippocampus abdominalis improves exercise performance and exerts anti-fatigue effects via AMPK/PGC-1 alpha pathway in mice

作者：Zhang, Yuanyuan[1,2];Ryu, Bomi[3];Cui, Yuhua[4];Li, Chengyong[1,5];Zhou, Chunxia[2];Hong, Pengzhi[2];Lee, Beajin[6];Qian, Zhong-Ji[1,5]

机构：[1]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518114, Guangdong, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Guangdong, Peoples R China;[3]Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea;[4]Shenzhen Wanqi Marine Biotechnol Co Ltd, Shenzhen 518114, Guangdong, Peoples R China;[5]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Guangdong, Peoples R China;[6]Marine Bioproc Co Ltd, Busan, South Korea

年份：2019

卷号：61

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：SCI-EXPANDED(收录号：WOS:000485205700016)、、WOS

基金：The research was funded by the Yangfan Scarce Top Talent Project of Guangdong Province (201433009) and the Program for Postgraduate Courses and Education Reform and Scientific Research Start-Up Funds of Guangdong Ocean University (to Z.-J.Q.). Additional support was provided by Guangdong Tongde Pharmaceutical Co., Ltd. and the National Engineering Research Center for Modernization of Traditional Chinese Medicine (Lingnan Medicinal Plant Oil Branch) and by the Development Project about Marine Economy Demonstration of Zhanjiang City (2017C8B1).

语种：英文

外文关键词：Hippocampus abdominalis; Peptide; Anti-fatigue; C57BL/6 mice; Exercise performance

外文摘要：Seahorse is been used as a traditional Chinese medicine and invigorant for many years. Among, the seahorse is considered to have anti-fatigue effects. However, few researches have demonstrated such an effect. This study, the anti-fatigue effect of a novel peptide purified (SH200) from the seahorse (Hippocampus abdominalis) was investigated in C57BL/6 mice. The effect of SH200 on exercise performance was assessed using a Rotarod test and clinical biochemical parameters. In addition, the expression levels of muscular-associated proteins were examined by western blot and immunohistochemical analysis. The results revealed that SH200 prolonged the running time of mice, reduced the expression of creatine, CK, LDH, L-lactate, Citrate, and increased the production serum glucose and FFA, hepatic glycogen, ATP, and SDH. Addition, SH200 also improved mitochondrial function and protected muscle fibers via AMMPK/PGC-1 alpha signal pathway. Thus, the SH200 is a potential candidate natural agent that could be used to reduce physical fatigue.