文献类型：期刊文献

英文题名：Theragra chalcogramma Hydrolysate, Rich in Gly-Leu-Pro-Ser-Tyr-Thr, Alleviates Photoaging via Modulating Deposition of Collagen Fibers and Restoration of Extracellular Components Matrix in SD Rats

作者：Xu, Defeng[1,2];Li, Caihong[3];Zhao, Mouming[4]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Engn Technol Res Ctr Marine Food, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[2]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China;[3]Guangdong Med Univ, Sch Basic Med Sci, Dongguan 523808, Peoples R China;[4]South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China

年份：2022

卷号：20

期号：4

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000785577900001)、、WOS

基金：The authors gratefully acknowledge the State Key Research and Development Plan (No. 2017YFD0400200), the Fundamental Research Funds for the Central Universities (No. 20152M062), and the Natural Science Foundation of PHD researchers of Guangdong Province in 2018 (2018A030310111) for the financial support.

语种：英文

外文关键词：photoaging; TCH; ECM metabolism; MMP-1; pathological restoration

外文摘要：Excessive exposure of the skin to ultraviolet irradiation induces skin photoaging, which seriously deteriorates the barrier functions of skin tissue, and even causes skin damages and diseases. Recently, dietary supplements from marine sources have been found to be useful in modulating skin functions and can be used to alleviate photoaging. Herein, the low-molecular-weight hydrolysates with a photoaging-protection effect were prepared by enzymatic hydrolysis from Theragra chalcogramma (TCH), and the potential mechanism were subsequently explored. The results revealed that TCH desirably improved the barrier functions of photoaged skin and stimulated the deposition of ECM components Col I, Hyp, and HA in the dermal layer. Histologically, TCH reduced the epidermal hyperplasia and restored the impaired architectures in a dose-dependent manner. Meanwhile, the activity of matrix metalloproteinase-1 (MMP-1) in photoaging skin was inhibited, and the expression levels of elastin and fibrillin-1 were elevated accordingly after TCH administration, and the significant improvements were observed at high-dose level (p < 0.05). Taken together, the efficacy of TCH against skin photoaging is highly associated with the regulation on ECM metabolism and the repairing of damaged mechanical structure.