文献类型：期刊文献

英文题名：A graphene-based electrochemical sensor for sensitive detection of paracetamol

作者：Kang, Xinhuang[1,2];Wang, Jun[1];Wu, Hong[1];Liu, Jun[1];Aksay, Ilhan A.[3];Lin, Yuehe[1]

机构：[1]Pacific NW Natl Lab, Richland, WA 99352 USA;[2]Guangdong Ocean Univ, Coll Sci, Zhanjiang 524088, Peoples R China;[3]Princeton Univ, Dept Chem Engn, Princeton, NJ 08544 USA

年份：2010

卷号：81

期号：3

起止页码：754

外文期刊名：TALANTA

收录：SCI-EXPANDED(收录号：WOS:000276877500002)、、EI(收录号：20101112769574)、Scopus(收录号：2-s2.0-77949283983)、WOS

基金：The work was supported by a laboratory-directed research and development program at Pacific Northwest National Laboratory (PNNL). The TEM and SEM works described in this paper were performed at the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by DOE's Office of Biological and Environmental Research and located at PNNL. PNNL is operated for DOE by Battelle under Contract DE-AC05-76RL01830. X. Kang gratefully acknowledges the award of a PNNL fellowship to perform this work at PNNL. Ilhan A. Aksay acknowledges support from Army Research Office (ARO)/Multidisciplinary Research Initiative (MURI) under grant number W911NF-04-1-0170, W911F-09-1-0476, and the Directed Technologies, Inc.

语种：英文

外文关键词：Graphene; Paracetamol; Square-wave voltammetry; Pharmaceutical preparation tablets

外文摘要：An electrochemical sensor based on the electrocatalytic activity of functionalized graphene for sensitive detection of paracetamol is presented. The electrochemical behaviors of paracetamol on graphene-modified glassy carbon electrodes (GCEs) were investigated by cyclic voltammetry and square-wave voltammetry. The results showed that the graphene-modified electrode exhibited excellent electrocatalytic activity to paracetamol. A quasi-reversible redox process of paracetamol at the modified electrode was obtained, and the over-potential of paracetamol decreased significantly compared with that at the bare GCE. Such electrocatalytic behavior of graphene is attributed to its unique physical and chemical properties, e.g., subtle electronic characteristics, attractive pi-pi interaction, and strong adsorptive capability. This electrochemical sensor shows an excellent performance for detecting paracetamol with a detection limit of 3.2 x 10(-8) M, a reproducibility of 5.2% relative standard deviation, and a satisfied recovery from 96.4% to 103.3%. The sensor shows great promise for simple, sensitive, and quantitative detection and screening of paracetamol. (C) 2010 Elsevier B.V. All rights reserved.