文献类型：期刊文献

英文题名：Modular construction of functionalized anilines via switchable C-H and N-alkylations of traceless N-nitroso anilines with olefins

作者：Ouyang, Wensen[1];Liu, Bairong[1];He, Yi[1];Wen, Yanmei[2];Gao, Yang[1];Huo, Yanping[1];Chen, Qian[1];Li, Xianwei[1]

机构：[1]Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China;[2]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China

年份：2022

卷号：9

期号：10

起止页码：2746

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：SCI-EXPANDED(收录号：WOS:000782946500001)、、EI(收录号：20221912090744)、Scopus(收录号：2-s2.0-85129661655)、WOS、CCR-EXPANDED(收录号：WOS:000782946500001)

基金：We are grateful for financial support from the National Natural Science Foundation of China (No. 22071034, U2001222, and 21975055), the Project of Enhancing School with Innovation of Guangdong Ocean University (No. 230419054), and the Guangdong Natural Science Foundation (No. 2021A1515010304).

语种：英文

外文摘要：A switchable C-H alkylation and N-alkylation with great chemo- and site-selectivity enabled by N-nitroso anilines was developed, affording functionalized anilines, hydrazines and heterocycles. The exploration of strain-release as the key driving force with structurally diverse olefins enabled mild and practical sequential C-H and C-C or C-O cleavage. Notably, N-nitroso anilines could act as traceless directing groups to enable indole synthesis via dehydrogenative coupling with styrenes.