文献类型：期刊文献

中文题名：马尾藻岩藻聚糖硫酸酯纯化及降血脂功能研究

英文题名：Study on the Purification and Lowing Hyperlipidemia Activity of Fucoidan from Sargassum henslowianum

作者：谌素华[1];王维民[1];刘辉[1];李春莲[1];刘承颖[1]

机构：[1]广东海洋大学食品科技学院,广东湛江524025

年份：2010

卷号：36

期号：5

起止页码：28

中文期刊名：食品与发酵工业

外文期刊名：Food and Fermentation Industries

收录：CSTPCD、、CSCD2011_2012、北大核心2008、北大核心、CSCD

基金：广东省科技厅资助项目(2007A020200006-15)

语种：中文

中文关键词：亨氏马尾藻;岩藻聚糖硫酸酯;纯化;降血脂

外文关键词：Sargassum henslowianum,fucoidan,purification,hyperlipidemia

中文摘要：以亨氏马尾藻为原料,运用超声波浸提工艺提取得到的岩藻聚糖硫酸酯(SPF),采用乙醇分级沉淀法纯化后经脱脂、脱蛋白得到初级纯化的岩藻聚糖硫酸酯,喂食高血脂症的小鼠,探讨其降血脂的功能。结果表明:亨氏马尾藻岩藻聚糖硫酸酯高、中、低3个剂量组的降血脂效果都优于药品对照脂必妥的降血脂效果,并且以高剂量的降血脂效果最佳,能够极显著(P<0.01)的降低总胆固醇、低密度脂蛋白、甘油三酯的含量,能显著(P<0.05)提高高密度脂蛋白的含量,且高于空白组;能显著降低动脉硬化指数,动脉粥样硬化指数AI1和AI2都有极显著影响(P<0.01)。说明亨氏马尾藻初级岩藻聚糖硫酸酯多糖具有明显的降血脂功能。

外文摘要：The Sulfated fucan （SPF） was extracted by ultrasonic extraction process from the Sargassum henslowianum, purified by ethanol, and then defatted, deproteinized to the primary fucoidan. The hyperlipidemia mice fed with purified primary fucoidan showed that： the hypolipidemia effect of the high, medium and low dose of fucoidan were all superior to the zhinbiticose. And the high dose was the best. The total cholesterol, low - density lipoprotein, triglyceride were all decreased significantly （ P 〈 0.01 ）, and high - density lipoprotein was increased significantly （P 〈0.05） than the control group. Arteriosclerosic index, AI1 and AI2 was decreased significantly（P 〈0.01 ）. The conclusion is that the Sulfated fucan from Sargassum henslowianum has obvious activity on lowing hyperlipidemia.