详细信息
季铵化改性壳聚糖的制备及其凝血性能研究 被引量:9
Preparation of quaternary ammonium modified chitosan and its coagulation properties
文献类型:期刊文献
中文题名:季铵化改性壳聚糖的制备及其凝血性能研究
英文题名:Preparation of quaternary ammonium modified chitosan and its coagulation properties
作者:梁倩瑜[1];翁博雅[1];黄美茹[1];陈丽红[1];贺怡心[1];胡章[1]
机构:[1]广东海洋大学化学与环境学院应用化学系,广东湛江524088
年份:2023
卷号:52
期号:2
起止页码:389
中文期刊名:应用化工
外文期刊名:Applied Chemical Industry
收录:CSTPCD、、CSCD_E2023_2024、北大核心、CSCD、北大核心2020
基金:国家重点研发计划项目(2020YFD0901101);广东省普通高校重点项目(2022ZDZX2027);广东省大学生创新创业训练计划项目(S202210566071);广东海洋大学大学生创新团队项目(CXTD2021020)。
语种:中文
中文关键词:壳聚糖;季铵化改性;凝血
外文关键词:chitosan;quaternized modification;coagulation
中文摘要:为了对壳聚糖进行化学改性及探究其凝血性能,以来源丰富的壳聚糖为起始原料,通过亲核取代反应,开展季铵化改性,采用紫外-可见光谱、红外光谱及X-射线衍射进行结构表征,并在体外探索其凝血性能。化学结构表征结果表明,季铵化壳聚糖已经成功制备得到;季铵化壳聚糖(50 mg)的体外凝血时间为128.2 s,凝血指数为43.6%,血浆复钙时间为102.1 s,制备得到的季铵化壳聚糖具有较强的促凝血性能。
外文摘要:In order to chemically modify chitosan and explore its coagulation performance,chitosan with rich sources was used as the starting material to carry out quaternary ammonium modification through nucleophilic substitution reaction,the structure was characterized by ultraviolet-visible spectroscopy(UV-Vis),Fourier transform infrared spectroscopy(FTIR)and X-ray diffraction(XRD),and its coagulation properties were evaulated in vitro.The characterization results showed that quaternized chitosan had been successfully prepared.The quaternized chitosan(50 mg)had the coagulation time of 128.2 s in vitro,the blood clotting index of 43.6%,and the plasma recalcification time of 102.1 s.These results showed that quaternized chitosan had a strong procoagulant property.
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