文献类型：期刊文献

英文题名：Carboxymethyl cellulose and carboxymethyl chitosan-based composite nanogel as a stable delivery vehicle for oyster peptides: Characterization, absorption and transport mechanism

作者：Zhang, Pei[1,2];Chen, Zhongqin[1,2,3,4,5,6];Zhou, Longjian[1,2];Gao, Jialong[1,2,3,4,5,6];Zheng, Huina[1,2,3,4,5,6];Lin, Haisheng[1,2,3,4,5,6];Zhu, Guoping[1,2,3,4,5,6];Qin, Xiaoming[1,3,4,5];Cao, Wenhong[1,2,3,4,5,6]

机构：[1]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[3]Ctr Shellfish Proc Zhanjiang, Natl Res & Dev Branch, Zhanjiang 524088, Peoples R China;[4]Guangdong Prov Engn Technol Res Ctr Seafood, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[5]Guangdong Higher Educ Inst, Guangdong Prov Engn Lab Marine Biol Prod, Key Lab Adv Proc Aquat Prod, Zhanjiang 524088, Peoples R China;[6]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China

年份：2024

卷号：442

外文期刊名：FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001167853000001)、、EI(收录号：20240715555088)、Scopus(收录号：2-s2.0-85184757514)、WOS

基金：This work was financially supported by the Guangdong Basic and Applied Basic Research Foundation (2021A1515110621) , the Science and Technology Plan Project of Zhanjiang (2022A05038) , the Science and Technology Plan Project of Zhanjiang City (2021E05017) , the National Natural Science Foundation of China (32201971) , the Program for scientific research start-up funds of Guangdong Ocean University (060302042007) and the earmarked fund for CARS (CARS -49) .

语种：英文

外文关键词：Oyster peptides; Composite nanogel; Chemical stability; Hypoglycemic activity; Intestinal absorption; Transport mechanism

外文摘要：An oyster peptide (OPs)-loaded composite nanogel based on carboxymethyl cellulose and carboxymethyl chitosan (CMC@CMCS@OPs) was prepared, and the characterization, absorption and transport mechanism were further investigated. CMC@CMCS@OPs, a dense spherical microstructure with a diameter of similar to 64 nm, which enhanced the thermal and digestive stabilities of individual OPs and improved its retention rate of hypoglycemic activity in vitro. The swelling response and in-vitro release profiles showed that CMC@CMCS@OPs could help OPs achieve targeted and controlled release in the intestine. In addition, CMC@CMCS@OPs had no cytotoxicity on Caco-2 cells, and its apparent permeability coefficients increased 4.70-7.45 times compared with OPs, with the absorption rate increased by 129.38 %. Moreover, the transcytosis of CMC@CMCS@OPs nanogel occurred primarily through the macropinocytosis pathway, endocytosis pathway and intestinal efflux transporter-mediated efflux. Altogether, these results suggested that CMC@CMCS@OPs nanogel could be as an effective OPs delivery device for enhancing its stability and absorption.