文献类型：期刊文献

英文题名：Carboxymethyl chitosan-based electrospun nanofibers with high citral-loading for potential anti-infection wound dressings

作者：Li, Chengpeng[1,2];Luo, Xiaoyan[1,3];Li, Lefan[1,2];Cai, Ying[1,2];Kang, Xinhuang[1,2];Li, Puwang[3]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Zhanjiang Key Lab Marine Biomat Res, Zhanjiang 524088, Peoples R China;[3]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

年份：2022

卷号：209

起止页码：344

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000793754100004)、、EI(收录号：20242616342300)、Scopus(收录号：2-s2.0-85128239631)、WOS

基金：This work was financially supported by Natural Science Foundation of Guangdong Province, P.R.C (No. 2020A1515011011), Project of Zhanjiang Science & Technology Plan (2019A01014 and 2020A01032), Project of Enhancing School with Innovation of Guangdong Ocean University (GDOU2017052502).

语种：英文

外文关键词：Carboxymethyl chitosan; Pickering emulsion; Electrospinning

外文摘要：As a natural antibacterial agent with pleasant fragrance, citral possesses low aqueous solubility. To improve citral loading in hydrophilic nanofiber, Pickering emulsion electrospinning strategy was proposed for anti-infection dressing development. The in-situ aggerated beta-cyclodextrin-citral inclusion complex particles (beta CPs) were used as emulsion stabilizers, while citral and carboxymethyl chitosan (CMCS)/polyvinyl alcohol (PVA) mixed solutions were used as the inner "dispersed oil phase " and outer "continuous water phase ", respectively. The results of electronic microscope investigation shown beta CPs possessed regular cube appearances with a size of 5.5 +/- 2.2 mu m, which might improve the emulsion storage stability based on visual investigation. Moreover, randomly oriented and bead-on-string nanofibers with beta CPs uniformly distributed could be obtained under optimized compositions and electrospinning parameters. Despite volatilization during electrospinning, nanofibers with high citral loading possessed good antibacterial performance against Staphylococcus aureus and Escherichia coli. In vitro hemolysis test indicated that nanofibers were hemocompatible. In addition, both fiber matrix and citral could promote the proliferation of mouse fibroblast cells. And the permeability of the fibers was adjustable. Thus, CMCS/PVA/beta CPs/citral nanofibers could potentially protect wound from infection. In summary, CMCS/PVA/beta CPs/citral nanofibers seemed to be promising alternatives to conventional wound dressings.