文献类型：期刊文献

中文题名：珠母贝糖胺聚糖的结构初探及其生理活性

英文题名：The preliminary probe of structure and physiological activity of glycosaminoglycan from Pinctada martensis

作者：吴红棉[1];雷晓凌[1];洪鹏志[1];陈方[2];吴铁[2];艾春媚[2]

机构：[1]湛江海洋大学食品工程系,广东湛江524025;[2]广东医学院药理教研室,广东湛江524023

年份：2001

卷号：25

期号：2

起止页码：166

中文期刊名：水产学报

外文期刊名：Journal of Fisheries of China

收录：CSTPCD、、北大核心2000、Scopus、CSCD2011_2012、北大核心、CSCD

基金：广东省重点科技攻关课题 ( 97 6 6 )

语种：中文

中文关键词：马氏珠母贝;糖胺聚糖;结构;生理活性;抗肿瘤作用

外文关键词：Pinctada martensis; glycosaminoglycan; structure; physiological activity

中文摘要：以马氏珠母贝全脏器为原料提取、纯化后所得的珠母贝糖胺聚糖PG2 - 3- 2 ,经醋酸纤维素薄膜电泳显示其迁移率相对接近于 6 -硫酸软骨素 (C - 6 -S) ,红外光谱类似于C - 6 -S。抗肿瘤试验结果显示 :PG2 - 3- 2对体内S180肉瘤和艾氏腹水癌可显著增敏临床抗癌药的抑瘤作用 ,抑瘤率分别达 6 1.96 %与 46 .3%。并有抗凝血作用。

外文摘要：Glycosaminoglycan PG2-3-2 from whole viscera of Pinctada martensis was obtained after extraction and purification. The fraction showed that its migration rate was relatively near to that of Chondroitin 6-sulphate(C-6-S) by acetate film electrophoresis. The infrared spectra (IR) of it was similar to that of C-6-S. The result of antitumor test in vivo demonstrated that PG2-3-2 could obviously enhance the sensitivity of inhibitive function of clinical antiturmor drugs, the inhibition rates of which to Sarcoma 180 and Ehrlich's Ascipes Carcinoma(EAC) were 61.96% and 46.3% respectively. Moreover, PG2-3-2 had certain function of anticoagulant by the test in vitro.