文献类型：期刊文献

英文题名：THE EFFECTS OF DEOXYNIVALENOL (DON) ON THE GUT MICROBIOTA, MORPHOLOGY AND IMMUNE SYSTEM OF CHICKEN - A REVIEW

作者：Aguzey, Harry A.[1];Gao, Zhenhua[1];Wu Haohao[1];Cheng Guilan[1];Wu Zhengmin[1];Chen Junhong[1]

机构：[1]Guangdong Ocean Univ, Dept Anim Sci, Coll Agr, Zhanjiang 524088, Guangdong, Peoples R China

年份：2019

卷号：19

期号：2

起止页码：305

外文期刊名：ANNALS OF ANIMAL SCIENCE

收录：SCI-EXPANDED(收录号：WOS:000466984500005)、、Scopus(收录号：2-s2.0-85075288680)、WOS

语种：英文

外文关键词：deoxynivalenol; microbiota composition; immune system; intestinal morphology; mycotoxins

外文摘要：Feed contamination is a major cause of diseases outbreak in the poultry industry. There is a direct relationship between feeding, the intestinal microbiota and how the immune system responds to disease infestation. Cereals which form the bulk of poultry feed are mostly contaminated by mycotoxins of Fusarium origin. Adequate knowledge of mycotoxins and their effects on animals is necessary. Deoxynivalenol (DON) is a major contaminant of poultry feed. DON has the ability to bind with a large number of eukaryotic ribosomal subunits because of the presence of an epoxide group and these disrupt the activity of peptidyl transferase and the elongation or shortening of peptide chains. Deoxynivalenol has varying effect ranging from acute, overt diseases with high morbidity and death to chronic disease, decreased resistance to pathogens and reduced animal productivity. Deoxynivalenol also impairs the intestinal morphology, nutrient absorption, barrier function, and the innate immune response in chickens. This review highlights the impacts of deoxynivalenol on the immune system, intestinal microbiota composition and the morphology of chicken.