文献类型：期刊文献

英文题名：Chitosan Oligosaccharides Protect Sprague Dawley Rats from Cyclic Heat Stress by Attenuation of Oxidative and Inflammation Stress

作者：Lan, Ruixia[1];Li, Siqi[1];Chang, Qingqing[1];Zhao, Zhihui[1]

机构：[1]Guangdong Ocean Univ, Coll Agr, Dept Anim Sci, 1 Haida Rd, Zhanjiang 524088, Peoples R China

年份：2019

卷号：9

期号：12

外文期刊名：ANIMALS

收录：SCI-EXPANDED(收录号：WOS:000506636400073)、、Scopus(收录号：2-s2.0-85075983996)、WOS

基金：The authors appreciate the financial support for this investigation by the program for scientific research start-up funds of Guangdong Ocean University (101402/R18005).

语种：英文

外文关键词：chitosan oligosaccharides; heat stress; antioxidant; anti-inflammatory; Sprague Dawley rats

外文摘要：Simple Summary Heat stress has negative effects on animal health and performance, and chitosan oligosaccharides (COS) exhibits antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effects of COS alleviation of oxidative stress and inflammatory response in heat-stressed rats. The results indicated heat stress decreased (p < 0.05) growth performance; the relative weight of spleen and kidney; and the level of antioxidant enzymes and IL-10 in liver, spleen, and kidney, while it increased (p < 0.05) the MDA and inflammatory cytokines concentration. Dietary COS supplementation enhanced (p < 0.05) ADG, the relative weight of spleen and kidney, and the level of antioxidant enzymes and IL-10 in liver, spleen, and kidney. Collectively, COS was beneficial to heat-stressed rats by alleviating oxidative damage and inflammatory response. Abstract Chitosan oligosaccharides (COS) exhibits antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effects of COS on antioxidant system and inflammatory response in heat-stressed rats. A total of 30 male rats were randomly divided to three groups and reared at either 24 degrees C or 35 degrees C for 4 h/d for this 7-day experiment: CON, control group with basal diet; HS, heat stress group with basal diet; HSC, heat stress with 200mg/kg COS supplementation. Compared with the CON group, HS significantly decreased (p < 0.05) average daily gain (ADG); average daily feed intake (ADFI); the relative weight of spleen and kidney; the level of liver CAT, GSH-Px, T-AOC, and IL-10; spleen SOD, GSH-Px, GSH, and IL-10; and kidney SOD, GSH-Px, T-AOC, and IL-10, while significantly increased the MDA concentration in liver, spleen, and kidney; the liver IL-1 beta concentration; and spleen and kidney IL-6 and TNF-alpha concentration. In addition, dietary COS supplementation significantly improved (p < 0.05) ADG; the relative weight of spleen and kidney; the level of liver GSH-Px, spleen GSH-Px, GSH, and IL-10; and kidney GSH-Px, while significantly decreased (p < 0.05) liver IL-1 beta concentration under heat stress condition. Collectively, COS was beneficial to heat-stressed rats by alleviating oxidative damage and inflammatory response.