文献类型：期刊文献

英文题名：Effects of salinity on behavior and reproductive toxicity of BPA in adult marine medaka

作者：Chen, Zuchun[1]; Li, Xueyou[1]; Gao, Jiahao[1]; Liu, Yue[1]; Zhang, Ning[1,2]; Guo, Yusong[1]; Wang, Zhongduo[1]; Dong, Zhongdian[1,2]

机构：[1] Key Laboratory of Aquaculture in South China Sea for Aquatic Economic Animal of Guangdong Higher Education Institutes, College of Fishery, Guangdong Ocean University, Zhanjiang, 524088, China; [2] Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemiology for Aquatic Economic Animals, College of Fishery, Guangdong Ocean University, Zhanjiang, 524088, China

年份：2024

卷号：357

外文期刊名：Chemosphere

收录：EI(收录号：20241715969101)、Scopus(收录号：2-s2.0-85190953835)

语种：英文

外文关键词：Phenols - Risk assessment - Toxicity

外文摘要：Salinity is an important environmental factor influencing the toxicity of chemicals. Bisphenol A (BPA) is an environmental endocrine disruptor with adverse effects on aquatic organisms, such as fish. However, the influence of salinity on the biotoxicity of BPA and the underlying mechanism are unclear. In this study, we exposed marine medaka (Oryzias melastigma) to BPA at different salinities (0 psμ, 15 psμ, and 30 psμ) for 70days to investigate the toxic effects. At 0 psμ salinity, BPA had an inhibitory effect on the swimming behavior of female medaka. At 15 psμ salinity, exposure to BPA resulted in necrotic cells in the ovaries but not on the spermatozoa. In addition, BPA exposure changed the transcript levels of genes related to the nervous system (gap43, elavl3, gfap, mbpa, and α-tubulin) and the hypothalamic-pituitary-gonadal (HPG) axis (fshr, lhr, star, arα, cyp11a, cyp17a1, cyp19a, and erα); the expression changes differed among salinity levels. These results suggest that salinity influences the adverse effects of BPA on the nervous system and reproductive system of medaka. These results emphasize the importance of considering the impact of environmental factors when carrying out ecological risk assessment of pollutants. ? 2024