文献类型：期刊文献

英文题名：Low-molecular-weight oyster peptides ameliorate cyclophosphamide-chemotherapy side-effects in Lewis lung cancer mice by mitigating gut microbiota dysbiosis and immunosuppression

作者：Li, Jinzhen[1];Yang, Li[4];Li, Guiyan[1];Liu, Shiying[1];Cao, Wenhong[1,2];Lin, Haisheng[1,2];Chen, Zhongqin[1,2];Qin, Xiaoming[1,2];Huang, Jinzhi[3,5];Zheng, Huina[1,2,5]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[2]Shenzhen Inst Guangdong Ocean Univ, Shenzhen 518108, Peoples R China;[3]Guangdong Med Univ, Affiliated Hosp, Dept Obstet & Gynecol, Zhanjiang 524001, Peoples R China;[4]Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China;[5]Guangdong Ocean Univ, Coll Food Sci & Technol, 1 Haida Rd, Zhanjiang 524088, Peoples R China

年份：2022

卷号：95

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：SCI-EXPANDED(收录号：WOS:000863764500006)、、Scopus(收录号：2-s2.0-85135716934)、WOS

基金：We gratefully acknowledge the financial support provided by the Guangdong Province Modern Agricultural Industry Technology System Innovation Team Construction Project (Grant No.2022KJ146) . Special funds for science technology innovation and industrial development of Shenzhen Dapeng New District (Grant No. KJYF202101-07) , the earmarked fund for CARS (Grant No. CARS-49) , and the Postgraduate Education Innovation Project of Guangdong Ocean University (Grant No.202260) .

语种：英文

外文关键词：Low -molecular -weight oyster peptides; Lewis lung cancer; Cyclophosphamide; Immune regulation; Gut microbiota

外文摘要：Low-molecular-weight oyster peptides (LOPs) are typical bioactive peptides with ameliorated immunomodula-tory properties. However, the mechanism underlying its effect on immune functions and intestinal flora after chemotherapy has not been reported. In this study, Lewis lung cancer mice were used along with cytotoxic chemotherapy to establish model to investigate the ameliorative effects of LOPs on immunomodulatory function and intestinal flora structure. Our results showed that administration of LOPs alleviated weight loss, reduced spleen tissue damage, increased splenic T-lymphocytes, and markedly increased secretion of serum immuno-globulins and decreased inflammatory factors. Additionally, LOPs significantly increased the abundance of beneficial bacteria (Lactobacillus and Coriobacteriaceae_UCG) and decreased pathogenic bacteria (Clostridium) present in intestine. Hydrophobic amino acids and glutamate may be the underlying components to mitigate negative effects of chemotherapy. This study provides a theoretical basis for the use of LOPs as a nutritional base for the development of formula foods for cancer patients undergoing chemotherapy.