文献类型：期刊文献

中文题名：不同低分子质量κ-卡拉胶对高脂饮食小鼠降脂活性

英文题名：Hypolipidemic Activity ofκ-Carrageenans of Different Molecular Masses in Mice Fed High-Fat Diet

作者：蔡海珠[1];陈菁[1,2];张国芸[1];郑珊珊[1];覃海丽[1];何融[1];宋兵兵[1];钟赛意[1,2]

机构：[1]广东海洋大学食品科技学院,广东省水产品加工与安全重点实验室,广东省海洋生物制品工程实验室,广东省海洋食品工程技术研究中心,广东湛江524088;[2]广东海洋大学深圳研究院,广东深圳518108

年份：2026

卷号：47

期号：8

起止页码：240

中文期刊名：食品科学

外文期刊名：Food Science

收录：北大核心2023、、EI(收录号：20262120759005)、北大核心

基金：深圳市国际合作项目(GJHZ20240218114715029);深圳市科技重大专项(可持续发展专项)(KCXFZ20240903094014019);广东省高校重点领域专项(2023ZDZX2025);广东省高校科技创新团队项目(2021KCXTD021)。

语种：中文

中文关键词：κ-卡拉胶;低分子质量;降脂;高脂肥胖

外文关键词：κ-carrageenan;low molecular mass;lipid-lowering;high fat-induced obesity

中文摘要：本研究采用光催化降解法制备不同低分子质量κ-卡拉胶样品(5.2、15.5、36.2 kDa),通过高脂饮食诱导的肥胖小鼠模型系统评价其降脂功效。通过检测小鼠体质量、附睾脂肪质量、口服葡萄糖耐量、血清血脂4项(甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C))、炎症因子(白细胞介素-6(interleukin-6,IL-6)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α))、肝脏脂质含量以及肝脏、结肠和脂肪组织的病理形态学变化,综合评估不同分子质量κ-卡拉胶样品的活性差异。结果表明,所有降解κ-卡拉胶均表现出降脂活性,且效果呈现分子质量依赖性。其中,15.5 kDa的κ-卡拉胶表现出最优的综合降脂效果,能显著抑制高脂饮食小鼠的体质量和附睾脂肪质量增长(P<0.05),改善糖耐量异常;有效调节血脂水平,使血清TC、TG和LDL-C水平分别降低12.40%、8.74%和5.02%,并显著提升HDL-C水平(提升11.34%);同时,它能显著降低血清中炎症因子IL-6水平,并有效减轻肝脏脂肪变性。本研究揭示了κ-卡拉胶的降脂活性与其分子质量密切相关,且发现降脂效果并非随分子质量降低而简单增强。本研究为深入理解κ-卡拉胶的生物活性提供了新的实验证据,可为开发具有特定分子质量特征的κ-卡拉胶降脂功能性食品提供新的数据支持和理论参考。

外文摘要：In this study,the lipid-lowering effects ofκ-carrageenans with different molecular masses(5.2,15.5 and 36.2 kDa),prepared using a photocatalytic degradation method,were compared in a mouse model of obesity induced by a high-fat diet.Body mass,epididymal fat mass,oral glucose tolerance,four serum lipid parameters(triglycerides(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)),inflammatory factors(interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)),hepatic lipid content,and pathomorphological changes in the liver,colon,and adipose tissue of mice were measured.The results indicated that all degradedκ-carrageenans exhibited lipid-lowering activity in a molecular mass-dependent manner.Among these,the 15.5 kDaκ-carrageenan demonstrated the most pronounced lipid-lowering effect.It significantly inhibited body mass gain and epididymal fat accumulation in high-fat diet-fed mice(P<0.05)and alleviated impaired glucose tolerance,effectively regulating blood lipid levels,reducing serum TC,TG and LDL-C by 12.40%,8.74%,and 5.02%respectively,whilst significantly increasing HDL-C levels by 11.34%.Additionally,it significantly reduced serum levels of the inflammatory cytokine IL-6 and effectively alleviated hepatic steatosis.This study revealed that the lipid-lowering activity ofκ-carrageenan is closely related to its molecular mass,but does not simply increase as its molecular mass decreases.This study provides new experimental evidence for an in-depth understanding of the biological activity ofκ-carrageenan,and offers new data support and theoretical references for the development ofκ-carrageenan-based functional foods with specific molecular mass characteristics.